Assessment of elemental imbalance in women from a goiter-endemic region
Bibliographic Data
| ID | 5968536 |
|---|---|
| Authors | Evgenia M Stepanova (0000-0002-2223-1358, Far Eastern Branch of the Russian Academy of Sciences), Elena A Lugovaya (0000-0002-6583-4175, Far Eastern Branch of the Russian Academy of Sciences) |
| Year | 2024 |
| Volume | 31 |
| Issue | 8 |
| Pages | 608-617 |
| Publication date | 2024-12-27 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Ekologiya Cheloveka (Human Ecology (JOURNAL) |
| Journal identifiers | ISSN: 1728-0869 • E-ISSN: 2949-1444 |
| Publisher | ECO-Vector LLC (PUBLISHER • RU) |
| DOI | 10.17816/humeco642712 |
| OpenAlex | W4410124040 |
| Language | EN |
| References cited | 17 |
BACKGROUND: The presence of a persistent goiter endemic in the northern region of Russian Federation (Magadan) highlights the significance of this study. Endemic goiter is considered a manifestation of regional biogeochemical maladaptation, where the primary role in thyroid hyperplasia development is attributed to environmental goitrogens and macro- and microelement imbalances.AIM: To evaluate elemental imbalance using an integral indicator, which is the adaptation coefficient of the body’s elemental system, in young women at peak reproductive age, depending on their serum thyroid-stimulating hormone (TSH) levels.MATERIALS AND METHODS: The concentrations of 25 macro- and microelements in hair samples were determined using a spectrometric method. Serum TSH levels were measured using an immunochemiluminescent method with paramagnetic particles.RESULTS: The pattern of elemental imbalance in women with low-normal or high-normal TSH levels is similar in terms of elemental deficiencies. However, the total deficiency rate differed significantly, reaching 323% in the low-normal TSH group and 203% in the high-normal TSH group. Elemental excesses were rare and primarily found in the high-normal TSH group.CONCLUSION: The obtained data highlight the adaptation coefficient of the body’s elemental system as an informative marker of intra- and intersystem elemental shifts in assessing various functional states and risks. In the low-normal TSH group, this coefficient was 86.50 conventional units, slightly exceeding the value observed in the high-normal TSH group - 75.33 conventional units
Environmental health · Geography · Goiter · Thyroid · Chemistry · Climate Change and Health Impacts · Environmental Science · Human Health and Disease · Medicine · Thermoregulation and physiological responses · Environmental Chemistry · Internal Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |