Leveraging Multiple Populations across Time Helps Define Accurate Models of Human Evolution
A Reanalysis of the Lactase Persistence Adaptation
Bibliographic Data
| ID | 6067326 |
|---|---|
| Authors | Chenling Xu Antelope, Chenling Xu (0000-0001-9610-7627, University of California, Berkeley), Chenling Xu Antelope Chenling Xu Antelope, Davide Marnetto (0000-0001-9573-0601, University of Turin), Davide Marnetto Davide Marnetto, Fergal Casey (0000-0002-6781-8670, University of California, Merced), Fergal Casey Fergal Casey, Emilia Huerta-Sanchez, Emilia Huerta‐sánchez (0000-0002-1506-5494, University of California, Merced, corresponding author), Emilia Huerta-Sanchez Emilia Huerta-Sanchez |
| Year | 2017 |
| Volume | 89 |
| Issue | 1 |
| Pages | 81-81 |
| Publication date | 2017-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 0018-7143 • E-ISSN: 1534-6617 |
| Publisher | Project MUSE (PUBLISHER • US) |
| DOI | 10.13110/humanbiology.89.1.05 |
| PMID | 29285971 |
| OpenAlex | W2768653348 |
| Language | EN |
| Citations received | 5 |
| References cited | 22 |
Access to a geographically diverse set of modern human samples from the present time and from ancient remains, combined with archaic hominin samples, provides an unprecedented level of resolution to study both human history and adaptation. The amount and quality of ancient human data continue to improve and enable tracking the trajectory of genetic variation over time. These data have the potential to help us redefine or generate new hypotheses of how human evolution occurred and to revise previous conjectures. In this article, we argue that leveraging all these data will help us better detail adaptive histories in humans. As a case in point, we focus on one of the most celebrated examples of human adaptation: the evolution of lactase persistence. We briefly review this dietary adaptation and argue that, effectively, the evolutionary history of lactase persistence is still not fully resolved. We propose that, by leveraging data from multiple populations across time and space, we will fijind evidence of a more nuanced history than just a simple selective sweep. We support our hypotheses with simulation results and make some cautionary notes regarding the use of haplotype-based summary statistics to estimate evolutionary parameters
Adaptation (eye · Biology · Data science · Epistemology · Evolutionary biology · Haplotype · Human evolution · Machine learning · Persistence (discontinuity · Quality (philosophy · Selective sweep · Archaeology and ancient environmental studies · Artificial Intelligence · Computer Science · Digestive system and related health · Forensic Anthropology and Bioarchaeology Studies · Genetics
Molecular Evolutionary Genetics
Ancient human genome sequence of an extinct Palaeo-Eskimo
Genetic history of an archaic hominin group from Denisova Cave in Siberia
Genome-wide patterns of selection in 230 ancient Eurasians
Analysis of Gene Diversity in Subdivided Populations
Genome sequence of a 45,000-year-old modern human from western Siberia
Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
Southern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago
Convergent adaptation of human lactase persistence in Africa and Europe
Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in Europe
Genetic Signatures of Strong Recent Positive Selection at the Lactase Gene
A global reference for human genetic variation
An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia
Ancient human genomes suggest three ancestral populations for present-day Europeans
The complete genome sequence of a Neanderthal from the Altai Mountains
The Origins of Lactase Persistence in Europe
A Draft Sequence of the Neandertal Genome
Estimation of the Coancestry Coefficient
Population genomics of Bronze Age Eurasia
Estimating F -Statistics for the Analysis of Population Structure
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,63 |
| Citation span | 2018 - 2025 (8) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 5 |