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A Worldwide Analysis of AG Molecular Diversity Inferred from Serology

Bibliographic Data

ID6068110
AuthorsAlicia Sanchez‐maza (0000-0002-7714-2432, University of Geneva), A Sanchez-Mazas, E Butler-Brunner, R Butler (0000-0003-4701-5253), Rosario Calderón (0000-0001-9196-5323), André Chaventré, J-M Dugoujon, J M Dugoujon, M Hammond (0000-0001-5072-7150), M G Hammond, G Lefranc, Marie‐paule Lefranc (0000-0003-0116-9353), Hiroshi Matsumoto (0000-0001-7842-504X), L Osipova, L P Osipova (0000-0001-7602-1156), Constantina Politis (0000-0002-0272-7794), R Pullmann, André Langaney
Year2001
Volume73
Issue5
Pages637-659
Publication date2001-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueHuman Biology (JOURNAL)
Journal identifiersISSN: 0018-7143 • E-ISSN: 1534-6617
PublisherProject MUSE (PUBLISHER • US)
DOI10.1353/hub.2001.0074
PMID11758687
OpenAlexW2016990127
LanguageEN
Citations received1
References cited10

Ten population samples from different geographic origins were tested serologically for the AG polymorphism of human beta-lipoproteins. Their haplotype frequencies were used with previously published data to perform a wide analysis of AG genetic differentiations throughout the world. Coancestry coefficients were computed from weighted F(ST)s among populations by using a matrix of molecular distances among AG haplotypes, which is here determined on the basis of DNA studies. Coancestry coefficients derived from unweighted F(ST)s and more classical Prevosti distances were computed on the same data and used for a comparison. In all cases a highly significant correlation was found between genetics and geography on a worldwide scale, while the significance of the correlation with linguistics differed. A test of significance of the pairwise F(ST)s among populations also gave different results depending on whether the molecular distance matrix among AG haplotypes was included. Globally, this study shows that in spite of being highly significantly correlated to each other, different genetic distance measures can lead to different interpretations of the same data set. Moreover, the elucidation of the molecular models related to the presently known serological polymorphisms may represent an additional tool for analyzing such polymorphisms in human population genetics studies

Allele · Biology · Evolutionary biology · Gene · Genetic diversity · Haplotype · Pairwise comparison · Population · Population genetics · Statistics · Demography · Genetics · HIV Research and Treatment · interferon and immune responses · Mathematics · Peroxisome Proliferator-Activated Receptors

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Unique citing works1
Citations per year0,05
Citation span2004 - 2004 (1)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 1

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