Human dispersals based on a global phylogenetic analysis of JC virus isolates of genotype B1-b

Bibliographic Data

ID6135489
AuthorsHuai-Ying Zheng (The University of Tokyo), Tomokazu Takasaka (The University of Tokyo), Norikazu Ohno (Aichi Gakuin University), Chie Sugimoto (0000-0002-0488-2931, National Institute of Infectious Diseases), Tadaichi Kitamura (0000-0002-3009-2546, The University of Tokyo), Yoshiaki Yogo (The University of Tokyo)
Year2007
Volume115
Issue2
Pages83-89
Publication date2007-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAnthropological Science (JOURNAL)
Journal identifiersISSN: 0918-7960 • E-ISSN: 1348-8570
PublisherAnthropological Society of Nippon (PUBLISHER • JP)
DOI10.1537/ase.061017
OpenAlexW1995140338
LanguageEN
Citations received1
References cited36

JC virus (JCV) is a useful marker for tracing human dispersal. Four genotypes of JCV (CY, SC, B1-b, and MY) are mainly distributed in Asia. The population history of humans carrying CY, SC, or MY has been studied in some detail, but that of humans carrying B1-b remains poorly understood. The objective of this study was to gain insights into the population history of Asians carrying B1-b. A neighbor-joining phylogenetic tree was reconstructed from 26 complete B1-b DNA sequences from various regions of Asia. On the tree, the B1-b DNA sequences diverged into two clades, designated B1-b1 and B1-b2, each clustered with a high bootstrap probability. The split into B1-b1 and B1-b2 was estimated to have occurred about 20000 years ago, based on Ks values (synonymous substitutions per synonymous site) and the suggested rate of synonymous nucleotide substitutions. Comparison of the complete B1-b1 and B1-b2 sequences revealed that two single nucleotide polymorphisms (SNPs) between B1-b1 and B1-b2 occurred in a 610 bp region (the IG region) of the viral genome. Based on these SNPs, 145 B1-b isolates previously identified in the Old World were classified into B1-b1 or B1-b2. B1-b1 was widespread on the Asian continent, spreading from Northeast Siberia to West Asia. In contrast, B1-b2 was localized to part of South Asia, including South India and Sri Lanka. On the basis of the present findings, we inferred the dispersals of Asians carrying B1-b

Biological dispersal · Biology · Clade · Evolutionary biology · Gene · Genotype · Phylogenetic tree · Population · Demography · Full-Duplex Wireless Communications · Plant Virus Research Studies · Polyomavirus and related diseases · Genetics · Virology

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