Genetic Instrumental Variable Studies of Effects of Prenatal Risk Factors
Bibliographic Data
| ID | 7668784 |
|---|---|
| Authors | George L Wehby (0000-0001-7784-9908, University of Iowa, corresponding author), Stephanie Von Hinke Kessler Scholder, Stephanie Von Hinke (0000-0002-8272-076X, University of York) |
| Year | 2013 |
| Volume | 59 |
| Issue | 1 |
| Pages | 4-36 |
| Publication date | 2013-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Biodemography and Social Biology (JOURNAL) |
| Journal identifiers | ISSN: 1948-5565 • E-ISSN: 1948-5573 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/19485565.2013.774615 |
| PMID | 23701534 |
| PMCID | PMC3690512 |
| OpenAlex | W2049184929 |
| Language | EN |
| Citations received | 2 |
| References cited | 98 |
Identifying the effects of maternal risk factors during pregnancy on infant and child health is an area of tremendous research interest. However, policymakers are primarily interested in unraveling the causal effects of prenatal risk factors, not their associations with child health, which may be confounded by several unobserved factors. In this article, we evaluate the utility of genetic variants in three genes that have unequivocal evidence of being related to three major risk factors-CHRNA3 for smoking, ADH1B for alcohol use, and FTO for obesity-as instrumental variables for identifying the causal effects of such factors during pregnancy. Using two independent datasets, we find that these variants are overall predictive of the risk factors and are not systematically related to observed confounders, suggesting that they may be useful instruments. We also find some suggestive evidence that genetic effects are stronger during than before pregnancy. We provide an empirical example illustrating the use of these genetic variants as instruments to evaluate the effects of risk factors on birth weight. Finally, we offer suggestions for researchers contemplating the use of these variants as instruments
Biology · Confounding · Developmental psychology · Econometrics · Economics · Instrumental variable · Pregnancy · Prenatal alcohol exposure · Birth, Development, and Health · Demography · Folate and B Vitamins Research · Medicine · Obesity, Physical Activity, Diet · Psychology · Genetics · Internal Medicine
ALSPAC–The Avon Longitudinal Study of Parents and Children
Recognition of the Fetal Alcohol Syndrome in Early Infancy
Mendelian randomization
‘Mendelian randomization’
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Identification of Causal Effects Using Instrumental Variables
Specification Tests in Econometrics
Instrumental Variables Regression with Weak Instruments
Estimation of Limited Dependent Variable Models With Dummy Endogenous Regressors
Prenatal care demand and its effects on birth outcomes by birth defect status in Argentina
Smoking and body weight
Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies
Estimating a Household Production Function
A Genetic Instrumental Variables Analysis of the Effects of Prenatal Smoking on Birth Weight
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,17 |
| Citation span | 2014 - 2018 (5) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |