Single nucleotide variants in interferon system genes in indigenous and non-indigenous residents of the Arkhangelsk region
Bibliographic Data
Background: In addition to climatic and social factors, individual susceptibility to infectious diseases among residents of the North is influenced by nucleotide sequence variants in interferon system genes. The protein products of these genes are involved in the immune response. Aim: The study aimed to assess the prevalence of single nucleotide variants in interferon system genes (IFNAR1, IFNAR2, IFNGR1, IFNL4 (IL-28B)) in indigenous and non-indigenous residents of Arkhangelsk region. METHODS: A cross-sectional study was conducted on a random sample of adults aged 43–74 years residing in Arkhangelsk (N=232; 36.6% male). The study protocol included participant interviews and molecular genetic analysis to determine alleles and genotypes of the following single nucleotide variants: rs2257167 in IFNAR1, rs2229207 in IFNAR2, rs1327474 in IFNGR1, rs12979860 and rs8099917 in IFNL4 (IL-28B). The observed genotype distributions in indigenous and non-indigenous groups were evaluated for compliance with Hardy–Weinberg equilibrium and compared between the groups. Results: The study population included 86 indigenous and 146 non-indigenous residents of Arkhangelsk region. Among non-indigenous residents, the genotype distributions of the variants rs2229207 (IFNAR2) and rs12979860 (IFNL4 (IL-28B)) deviated from Hardy–Weinberg equilibrium due to an excess of heterozygotes. At the same time, for the rs1327474 (IFNGR1), the number of heterozygotes was lower than expected. The frequency of the C allele of rs2229207 (IFNAR2), associated with severe viral infections, was higher in the Arkhangelsk region population than in European and global populations. The homozygous CC genotype of rs2229207 (IFNAR2) was significantly less common in indigenous residents of the Arkhangelsk region (2.6%) than in non-indigenous residents (11.2%). A higher frequency of the heterozygous CT genotype of rs1327474 (IFNGR1) was observed in the non-indigenous residents. Conclusion: This study identified specific features of the genetic structure of the adult population of the Arkhangelsk region, shaped by migration from other regions to the North. These findings reflect a higher prevalence of genetic susceptibility markers for viral infections among the non-indigenous population of the European North
Biology · Gene · Genotype · Indigenous · Interferon · Nucleotide · Single-nucleotide polymorphism · Cytokine Signaling Pathways and Interactions · Hepatitis C virus research · Influenza Virus Research Studies · Genetics
| Citation velocity | historical |
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| Highly cited | No |