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Malnutrition and immunological function with special reference to cell-mediated immunity

Bibliographic Data

ID8313285
AuthorsLaurie Hoffman-Goetz, Laurie Hoffman‐goetz (University of Waterloo, corresponding author)
Year1986
Volume29
IssueS7
Pages139-159
Publication date1986-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.1330290506
OpenAlexW2117757471
LanguageEN
Citations received7
References cited132

Malnutrition, and especially undernutrition, is the most common cause of acquired immune dysfunction worldwide. Establishing a cause-effect relationship among nutritional variables, immunological function, and disease susceptibility has proved to be difficult. In this review, the degree to which macronutrient and micronutrient deficiencies affect cell-mediated immunity and immunoregulation is discussed. The evidence for malnutrition-immune response linkages is grouped according to in vitro studies of thymus gland morphology and function, peripheral T-lymphocyte number and responsiveness to antigens, and soluble immunoregulatory mediators, and in vivo studies of delayed hypersensitivity, graft rejection, and cytotoxicty. Limitations of these studies are considered in light of disease resistance/susceptibility to pathogens that evoke cell-mediated immune responses

Biology · Cellular immunity · Disease · Immune system · Immunity · Malnutrition · Micronutrient · Pathology · Child Nutrition and Water Access · Immunology · Iron Metabolism and Disorders · Medicine · Vitamin C and Antioxidants Research

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Unique citing works7
Citations per year0,23
Citation span1996 - 2018 (23)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 7

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