Brief communication
Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait
Bibliographic Data
| ID | 8314121 |
|---|---|
| Authors | Sarah Catherine Hill (0000-0003-1840-3767, Leverhulme Center for Human Evolutionary Studies University of Cambridge Cambridge CB2 1QH UK), Talal Ramadan Mohammad (Leverhulme Center for Human Evolutionary Studies University of Cambridge Cambridge CB2 1QH UK), Toomas Kivisild (0000-0002-6297-7808, Leverhulme Center for Human Evolutionary Studies University of Cambridge Cambridge CB2 1QH UK) |
| Year | 2013 |
| Volume | 152 |
| Issue | 1 |
| Pages | 140-144 |
| Publication date | 2013-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.22313 |
| PMID | 23913618 |
| OpenAlex | W1932570246 |
| Language | EN |
| Citations received | 2 |
| References cited | 32 |
Lactase persistence (LP)—the ability to digest lactose in adulthood—is paradigmatic of Holocenic dietary change affecting the evolutionary trajectory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. Here, we present new sequence data from a 427 bp amplicon 14 kb upstream of the LCT (lactase) gene for two Bedouin tribal populations, the Ajman and Mutran. We estimate the frequency of known LP associated alleles and discuss the impact of nomadic‐pastoralism on the associated genetic variation. We observe high frequency (56% on average) of the − 13,915*G allele in both tribes, which is consistent with the high prevalence of LP in Kuwait. Whilst LP associated alleles occur in Kuwait at a similar frequency to other regional populations, we suggest that the − 13,915*G allele frequency among the Kuwaiti Bedouin may be higher than among non‐Bedouin Kuwaitis, possibly due to greater historical reliance on milk consumption or genetic drift. Am J Phys Anthropol 152:140–144, 2013. © 2013 Wiley Periodicals, Inc
Allele · Allele frequency · Biology · Evolutionary biology · Gene · Genetic variation · Lactase · Lactose · Lactose intolerance · Persistence (discontinuity) · Subsistence agriculture · Demography · Digestive system and related health · Ecology · Food Science · Genetics · Nutrition, Genetics, and Disease
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| Unique citing works | 2 |
|---|---|
| Citations per year | 0,22 |
| Citation span | 2017 - 2026 (10) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 2 |