Human red cell glycolysis in high altitude chronic hypoxia
Bibliographic Data
| ID | 8314525 |
|---|---|
| Authors | J Arnaud (Hôpital Purpan), Nancy Gutierrez (Instituto Boliviano de Ciencia y Tecnología Nuclear) |
| Year | 1984 |
| Volume | 63 |
| Issue | 3 |
| Pages | 307-314 |
| Publication date | 1984-03-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330630307 |
| PMID | 6731602 |
| OpenAlex | W2041378726 |
| Language | EN |
| Citations received | 2 |
| References cited | 15 |
We have found that glycolysis in human red blood cells under the hypoxic conditions found at high altitudes is connected with changes in enzyme activities and levels of various metabolic intermediates. The sensitivity of the four kinases to hypoxia results in 1) glycolytic hyperactivity leading to a higher intracellular energy state, and 2) accumulation of 2–3 DPG, whose role in the adaptation of red blood cell respiration to high altitude has been shown by previous research. PEP, 3PG, and G6P appear to be the main regulating intermediates in glycolysis in this system. The reason for the very large increase in G1‐6DP is still not clear
Adaptation (eye) · Biology · Cell · Effects of high altitude on humans · Enzyme · Glycolysis · Hypoxia (environmental) · Intracellular · Kinase · Oxygen · Respiration · Anatomy · Biochemistry · Cell Biology · Chemistry · Erythrocyte Function and Pathophysiology · Hemoglobin structure and function · Neonatal Health and Biochemistry · Neuroscience
| Citations per year | 0.05 |
|---|---|
| Citation span | 1985 - 1999 (15) |
| Highly cited | No |