Haplotypes of α‐globin gene regulatory element in two Brazilian native populations

Bibliographic Data

ID8315607
AuthorsDaniela Maria Ribeiro (Universidade Estadual de Campinas (UNICAMP)), Maria Stella Figueiredo (0000-0003-3977-9915, Universidade Federal de São Paulo), Fernando Ferreira Costa (0000-0002-4632-572X, Universidade Estadual de Campinas (UNICAMP)), Maria De Fatima Sonati (0000-0002-5193-8854, Universidade Estadual de Campinas (UNICAMP), corresponding author)
Year2003
Volume121
Issue1
Pages58-62
Publication date2003-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.10193
PMID12687583
OpenAlexW1995299031
LanguageEN
Citations received4
References cited24

The α‐major regulatory element (α‐MRE), located 40 Kb far upstream of the α‐globin gene cluster on chromosome 16, is involved in the regulation of human α‐globin genes expression. The activity of this element is restricted to a 350‐bp fragment in which several nuclear protein binding sites have been identified. This element is genetically polymorphic and different haplotypes, named A–F, have been determined in seven populations of Europe, Africa, Asia, and Oceania. We describe here the α‐MRE haplotypes found in native Indians from two nonmiscegenated tribes of the north region of Brazil, in Amazonia, the Parakanã and the Xikrin. The A haplotype was predominant in both (70% and 87%, respectively), followed by the B haplotype (30% and 13%, respectively). The haplotype frequency distribution among the Parakanã was similar to that reported for Indonesians and Southeast Asian populations, while the distribution among the Xikrin showed higher similarity to that observed in Indonesians. These results corroborate the existence of genetic affinities between Brazilian Indians and Southeast Asian and Oceanic populations. This was the first investigative work on the α‐MRE polymorphism in South American native populations in general or Brazilian native populations in particular. Am J Phys Anthropol 121:000–000, 2003. © 2003 Wiley‐Liss, Inc

Affinities · Biology · Evolutionary biology · Gene · Genotype · Globin · Haplotype · Folate and B Vitamins Research · Genetics · Hemoglobinopathies and Related Disorders · Iron Metabolism and Disorders

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