The founder effect in a human isolate
Evolutionary implications
Bibliographic Data
| ID | 8315665 |
|---|---|
| Authors | Alice O Martin, Alice Martin (0000-0002-9023-506X, Office of the Director, corresponding author) |
| Year | 1970 |
| Volume | 32 |
| Issue | 3 |
| Pages | 351-367 |
| Publication date | 1970-05-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.1330320305 |
| PMID | 5419373 |
| OpenAlex | W2129212181 |
| Language | EN |
| Citations received | 8 |
| References cited | 22 |
An investigation of the founder effect has been made on the H‐leut, a religious isolate. Ninety‐one founders, representing a maximum of 150 independent genomes, have been shown to account for the total gene pool of the 9,536 people in two of the three major subpopulations within the isolate, the S‐leut and the L‐leut. Each of these two leut is subdivided into four clans which in turn are subdivided into colonies. Malécot's coefficient of kinship has been calculated between each of the 91 founders and the contemporary parents, and used to describe the relative genetic contributions of the founders to the gene pool of each subpopulation. Analysis of this distribution suggests that a considerable amount of genetic diversity may be attributable to the founder effect. Part of this diversity may be accounted for by variation in the birth dates of the founders. The size of the subset of the 91 founders related to each subpopulation decreases with decreasing subpopulation level. A correlation has been found between two measures of relationship between pairs of clans: (1) Kurczynski's modification of Mahalanobis's distance measure based on gene frequency differences; and (2) a comparison of the relative contributions of founders to the gene pools of the clans
Biology · Clan · Evolutionary biology · Founder effect · Gene · Genetic diversity · Genetic variation · Genotype · Haplotype · Kinship · Mahalanobis distance · Population · Sociology · Statistics · Anthropology · Demography · Evolution and Genetic Dynamics · Genetic diversity and population structure · Genetic Mapping and Diversity in Plants and Animals · Genetics · Mathematics
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Patterns of cancer in geographic and endogamous subdivisions of the Hutterite Brethren of Canada
The development of genetics and population studies
Demographic components of gene frequency change in free‐ranging macaques on Cayo Santiago
Inbreeding and surnames
The Demography of Colony Fission from 1878-1970 Among the Hutterites of North America
Nonparametric statistics for the behavioral sciences
Animal Species and Evolution
Phylogeographic relationships within the Mediterranean turbot inferred by mitochondrial DNA haplotype variation
Coefficients of Inbreeding and Relationship
On the evidence of random genetic drift in human populations
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All Things Common
All Things Common
| Unique citing works | 8 |
|---|---|
| Citations per year | 0,15 |
| Citation span | 1972 - 2006 (35) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 7 |