The skeletal manifestation of malaria
An epidemiological approach using documented skeletal collections
Bibliographic Data
| ID | 8317709 |
|---|---|
| Authors | Nicole E Smith-Guzm ́an (0000-0002-3743-6188, Department of Anthropology University of Arkansas Fayetteville AR 72701, corresponding author), Nicole E Smith‐Guzmán |
| Year | 2015 |
| Volume | 158 |
| Issue | 4 |
| Pages | 624-635 |
| Publication date | 2015-12-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.22819 |
| PMID | 26213353 |
| OpenAlex | W1559474708 |
| Language | EN |
| Citations received | 39 |
| References cited | 50 |
OBJECTIVES: Recent studies in paleopathology have shown promise in associating some skeletal lesions with malarial infection. However, malaria's skeletal manifestation has never been confirmed using a large clinical reference sample from an endemic area for malaria with known individual causes of death. MATERIALS AND METHODS: To pinpoint evidence of malaria infection on ancient skeletal remains, this study uses an epidemiological approach to compare skeletal lesions in a modern reference sample of 98 individuals from Uganda, where malaria is holoendemic, to a similar modern sample of 106 individuals from a malaria-free area. RESULTS: Five porous skeletal lesions are identified that appear more frequently in the endemic area population, especially in anemic individuals. These appear on the cranium, vertebral column, and humeral and femoral necks. Periostitis also associates strongly with individuals in the endemic population; however, linear enamel hypoplasias show an inverse association. The identified lesions are tested for their association with each other, and then tested individually for their diagnostic power through measures of sensitivity and specificity. A diagnostic outcome algorithm is formed from the remaining skeletal lesions and their inter-lesion associations. DISCUSSION: Several etiological explanations for the characteristic malarial skeletal lesions are explored, including severe malarial anemia, an imbalance in bone remodeling, and extramedullary erythropoiesis. The importance of careful differential diagnoses between other infectious and noninfectious causes of these lesions is discussed, including the potential for coinfection of malaria with other infectious diseases. The findings of this study are pivotal in establishing diagnostic criteria by which we can identify the prevalence and impact of malaria on past populations
Axial skeleton · Environmental health · Etiology · Malaria · Paleopathology · Pathology · Periostitis · Population · Anatomy · Epidemiology · Forensic and Genetic Research · Forensic Anthropology and Bioarchaeology Studies · Medicine · Paleopathology and ancient diseases
Porous skeletal lesions in perspective
Bioarqueología de Las Papas (Departamento Tinogasta, Catamarca)
Two cases of concha bullosa in a contemporary Cypriot skeletal collection
Death and the City
Periostitis as an Indicator of the Impact of Subadult Stress
Human-Animal Interactions and Infectious Disease
Compounding vulnerabilities
Bioarchaeological reconstruction of physiological stress during social transition in Albania
Tentative indicators of malaria in archaeological skeletal samples, a pilot study testing different methods
Cribriotic lesions in archaeological human skeletal remains. Prevalence, co-occurrence, and association in medieval and early modern Netherlands
Life and death at the “The Land of Three Lakes”
Caring for the sick in a medieval rural community
An isthmus of isolation
The people behind the samples
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Nested Environments
A Possible Case of β‐Thalassemia From the Cemetery of Santa Maria Maggiore in Vercelli (Piedmont, Northern Italy,18th Century)
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Evaluation of rapid diagnostic tests and Enzyme Linked Immunoassay in the detection of malaria in ancient human remains
Skeletal manifestations of anemia in the sternum in a modern clinical sample
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Possible thalassemia intermedia in a child (16th–18th century) from the westernmost part of Europe
Stress markers and survivorship over the last 2,000 years in Milanese females and males
The God Shed at Amarna
Effect of Subadult Stress—Cribra Orbitalia and Linear Enamel Hypoplasia on Adult Mortality in Late Antique Southern Pannonia
Cribra orbitalia and cribra cranii in perspective
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Evaluating the relationships between climate change, population pressure, economic intensification, and childhood stress in the Prehispanic Nasca region of Peru
Allen's fossa —An attempt to dissolve the confusion of different nonmetric variants on the anterior femoral neck
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Babes, bones, and isotopes
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Mortality Crisis at Akhetaten? Amarna and the Bioarchaeology of the Late Bronze Age Mediterranean Epidemic
Villa Estates and Malaria Risk in Roman Central Italy
Mother City and Colony
Frequency and co-occurrence of porous skeletal lesions in identified non-adults from Portugal (19th to 20th centuries) and its association with respiratory infections as cause of death
Growth faltering in a skeletal sample of enslaved nonadult Africans found at Lagos, Portugal (15th-17th centuries)
Porotic Hyperostosis, Anemias, Malarias, and Marshes in the Prehistoric Eastern Mediterranean
A systematic analysis of global anemia burden from 1990 to 2010
Cribra orbitalia in the ancient Nile Valley and its connection to malaria
Extirpolation of the Mythology that Porotic Hyperostosis is Caused by Iron Deficiency Secondary to Dietary Shift to Maize
Immunological evidence of Plasmodium falciparum infection in an Egyptian child mummy from the Early Dynastic Period
Eighteenth-Century Carolina Health Conditions
Porotic hyperostosis
Epidemiological approach to the paleopathological diagnosis of leprosy
Variation of the anterior aspect of the femoral head‐neck junction in a modern human identified skeletal collection
Frontiers in the bioarchaeology of stress and disease
Developmental, diachronic, and demographic analysis of cribra orbitalia in the medieval christian populations of Kulubnarti
The etiology of porotic hyperostosis among the prehistoric and historic Anasazi Indians of Southwestern United States
The “cervical fossa” of Allen
The causes of porotic hyperostosis and cribra orbitalia
Morbidity in the marshes
Porotic hyperostosis
Is cribra orbitalia synonymous with anemia? Analysis and interpretation of cranial pathology in Sudan
Porotic hyperostosis and cribra orbitalia
Factors influencing the etiology of cribra orbitalia in prehistoric Nubia
Implications of Reappraising the Iron-Deficiency Anemia Hypothesis
Anemia, genetic diseases, and malaria in prehistoric mainland southeast Asia
Porotic lesions in immature skeletons from Stara Torina, late medieval Serbia
Malaria in antiquity
Can archaeologists excavate evidence of malaria
Malaria in Ancient Egypt
Parasites, Porotic Hyperostosis, and the Implications of Changing Perspectives
Part Two
| Unique citing works | 39 |
|---|---|
| Citations per year | 3,9 |
| Citation span | 2016 - 2026 (11) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 35 |