Evolution of a pigmentation gene, the melanocortin‐1 receptor, in primates
Bibliographic Data
| ID | 8318019 |
|---|---|
| Authors | Nicholas I Mundy (0000-0002-5545-1517, University of Oxford, corresponding author), Joanne Kelly (0000-0002-5037-9878, University of Oxford) |
| Year | 2003 |
| Volume | 121 |
| Issue | 1 |
| Pages | 67-80 |
| Publication date | 2003-04-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Physical Anthropology (JOURNAL) |
| Journal identifiers | ISSN: 0002-9483 • E-ISSN: 1096-8644 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajpa.10169 |
| PMID | 12687585 |
| OpenAlex | W2000167235 |
| Language | EN |
| Citations received | 6 |
| References cited | 37 |
The melanocortin‐1 receptor (MC1R) forms a critical switch in the production of orange/red pheomelanin and black/brown eumelanin pigments during hair development in mammals. The molecular evolution of the melanocortin‐1 receptor gene was investigated in a broad range of primate species, including several groups with large differences in distribution of orange/red and black hairs. Primate MC1R has been subject to purifying selection throughout most of its evolution, with small changes in selective constraint being detected early in primate evolution. In contrast to the situation in humans and domestic mammals, many intraspecific and intrageneric differences in primate coat color cannot be attributed to changes in the MC1R coding sequence. Nevertheless, important changes in the biochemical function of MC1R are suggested by mutations in sites of known functional importance, particularly in New World monkeys and lemurs. The evolution of the MC1R in lion tamarins is anomalous, with a combination of a high nonsynonymous to synonymous substitution rate (dN/dS) ratio, deletions, and substitutions. Am J Phys Anthropol 121:000–000, 2003. © 2003 Wiley‐Liss, Inc
Biology · Coat · Evolutionary biology · Gene · Genome · Intraspecific competition · Lemur · Melanocortin 1 receptor · Molecular evolution · Negative selection · Nonsynonymous substitution · Old World · Phenotype · Phylogenetics · Primate · Zoology · Biochemical Analysis and Sensing Techniques · Ecology · Genetics · melanin and skin pigmentation · Olfactory and Sensory Function Studies
European hair and eye color
Genetic characterization of Macaca arctoides
Did Trichromatic Color Vision and Red Hair Color Coevolve in Primates
Variation of the melanocortin 1 receptor gene in the macaques
The primate palette
Abnormal Pelage Color in an Isolated Population of Alouatta guariba clamitans Cabrera, 1940 in South Brazil
| Unique citing works | 6 |
|---|---|
| Citations per year | 0,3 |
| Citation span | 2006 - 2023 (18) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 4 |