Variation of the melanocortin 1 receptor gene in the macaques
Bibliographic Data
| ID | 19387809 |
|---|---|
| Authors | Kazuhiro Nakayama (0000-0003-1616-6163, The University of Tokyo), Takayoshi Shotake (Kyoto University), Osamu Takeneka (Kyoto University), Takafumi Ishida (0000-0002-0896-3069, The University of Tokyo, corresponding author) |
| Year | 2008 |
| Volume | 70 |
| Issue | 8 |
| Pages | 778-785 |
| Publication date | 2008-08-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | American Journal of Primatology (JOURNAL) |
| Journal identifiers | ISSN: 0275-2565 • E-ISSN: 1098-2345 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/ajp.20547 |
| PMID | 18454455 |
| OpenAlex | W2125958058 |
| Language | EN |
| Citations received | 1 |
| References cited | 45 |
Melanocortin 1 receptor (MC1R), a G‐coupled seven‐transmembrane receptor protein, plays a key role in the regulation of melanin synthesis in mammals. Sequence variation of the MC1R gene ( MC1R ) has been associated with pigmentation phenotypes in humans and in several animal species. The macaques (genus Macaca ) are known to show a marked inter‐specific variation in coat color although the causative genetic variation remains unclear. We investigated nucleotide sequences of the MC1R in 67 individuals of 18 macaque species with different coat color phenotypes including black and agouti. Twenty‐eight amino acid replacements were identified in the macaques, but none of these amino acid replacements could explain the black coat color of Macaca silenus and the Sulawesi macaque species. Our molecular evolutionary analysis has revealed that nonsynonymous substitution/synonymous substitution (d N /d S ) ratio of the MC1R has not been uniform in the macaque groups and, moreover, their coat color and d N/ d S ratio were not related. These results suggest that the MC1R is unlikely to be responsible for the coat color variation of the macaques and functions of MC1R other than pigmentation might be associated with the different selective pressures on the MC1R in macaques. Am. J. Primatol. 70:778–785, 2008. © 2008 Wiley‐Liss, Inc
Biology · Coat · Evolutionary biology · Gene · Genetic variation · Macaque · Melanocortin 1 receptor · Nonsynonymous substitution · Phenotype · Rhesus macaque · Biochemical Analysis and Sensing Techniques · melanin and skin pigmentation · Regulation of Appetite and Obesity · Ecology · Genetics
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,07 |
| Citation span | 2011 - 2011 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |