Genetic diversity in S vaneti and its implications for the human settlement of the H ighland C aucasus
Bibliographic Data
OBJECTIVES: In this study, we characterized genetic diversity in the Svans from northwestern Georgia to better understand the phylogeography of their genetic lineages, determine whether genetic diversity in the highland South Caucasus has been shaped by language or geography, and assess whether Svan genetic diversity was structured by regional residence patterns. MATERIALS AND METHODS: We analyzed mtDNA and Y-chromosome variation in 184 individuals from 13 village districts and townlets located throughout the region. For all individuals, we analyzed mtDNA diversity through control region sequencing, and, for males, we analyzed Y-chromosome diversity through SNP and STR genotyping. The resulting data were compared with those for populations from the Caucasus and Middle East. RESULTS: We observed significant mtDNA heterogeneity in Svans, with haplogroups U1-U7, H, K, and W6 being common there. By contrast, ∼78% of Svan males belonged to haplogroup G2a, with the remainder falling into four other haplogroups (J2a1, I2, N, and R1a). While showing a distinct genetic profile, Svans also clustered with Caucasus populations speaking languages from different families, suggesting a deep common ancestry for all of them. The mtDNA data were not structured by geography or linguistic affiliation, whereas the NRY data were influenced only by geography. DISCUSSION: These patterns of genetic variation confirm a complex set of geographic sources and settlement phases for the Caucasus highlands. Such patterns may also reflect social and cultural practices in the region. The high frequency and antiquity of Y-chromosome haplogroup G2a in this region further points to its emergence there
Allele · Biology · Evolutionary biology · Gene · Genetic diversity · Genetic variation · Geography · Haplogroup · Haplotype · mtDNA control region · Phylogenetics · Phylogeography · Population · Demography · Forensic and Genetic Research · Forensic Anthropology and Bioarchaeology Studies · Genetic Associations and Epidemiology · Genetics
HaploGrep
Genome-wide patterns of selection in 230 ancient Eurasians
Early farmers from across Europe directly descended from Neolithic Aegeans
Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities
Sequence and organization of the human mitochondrial genome
Multiple Regression and Correlation Extensions of the Mantel Test of Matrix Correspondence
Where West Meets East
Correcting for Purifying Selection
The Eurasian Heartland
Pleistocene Mitochondrial Genomes Suggest a Single Major Dispersal of Non-Africans and a Late Glacial Population Turnover in Europe
Median-joining networks for inferring intraspecific phylogenies
Polarity and Temporality of High-Resolution Y-Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists
New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree
Excavating Y-chromosome haplotype strata in Anatolia
Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA
Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans
Arlequin suite ver 3.5
Tracing European Founder Lineages in the Near Eastern mtDNA Pool
Phylogeography of mitochondrial DNA in western Europe
A “Copernican” Reassessment of the Human Mitochondrial DNA Tree from its Root
Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation
The Molecular Dissection of mtDNA Haplogroup H Confirms That the Franco-Cantabrian Glacial Refuge Was a Major Source for the European Gene Pool
The Origin and Diversification of Language
Mitochondrial DNA haplogroup diversity in Basques
The History of Armenia
Clan, language, and migration history has shaped genetic diversity in Haida and Tlingit populations from Southeast Alaska
Genetic heritage and native identity of the Seaconke Wampanoag tribe of massachusetts
Genetic ancestry and indigenous heritage in a Native American Descendant Community in Bermuda
Genetic diversity in P uerto R ico and its implications for the peopling of the I sland and the W est I ndies
Human Paternal Lineages, Languages, and Environment in the Caucasus
Correlation of annual precipitation with human Y-chromosome diversity and the emergence of Neolithic agricultural and pastoral economies in the Fertile Crescent
The Good Russian Prisoner
Biological Ancestries, Kinship Connections, and Projected Identities in Four Central Anatolian Settlements
| Citation velocity | historical |
|---|---|
| Highly cited | No |