Heterogeneous frailty and the expression of linear enamel hypoplasia in a genealogical population

Bibliographic Data

ID8320181
AuthorsJulie Lawrence (0000-0002-6198-7772, Center for Bioarchaeological Research, School of Human Evolution and Social Change Arizona State University Tempe Arizona USA, corresponding author), C M Stojanowski (0000-0003-3866-4999, Center for Bioarchaeological Research, School of Human Evolution and Social Change Arizona State University Tempe Arizona USA), K S Paul (0000-0001-9744-4203, Department of Anthropology University of Arkansas Fayetteville Arkansas USA), Andrew C Seidel (0000-0002-9244-7947, Center for Bioarchaeological Research, School of Human Evolution and Social Change Arizona State University Tempe Arizona USA), D Guatelli-Steinberg (0000-0002-1345-5384, Department of Anthropology The Ohio State University Columbus Ohio USA)
Year2021
Volume176
Issue4
Pages638-651
Publication date2021-12-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.24288
PMID33852741
OpenAlexW3154495408
LanguageEN
Citations received6
References cited88

OBJECTIVES: Linear enamel hypoplasia (LEH) is a common skeletal marker of physiological stress (e.g., malnutrition or illness) that is studied within and across populations, without reference to familial risk. We examine LEH prevalence in a population with known genealogical relationships to determine the potential influence of genetic heritability and shared environment. METHODS: LEH data of 239 individuals from a single population were recorded from the Ohio State University Menegaz-Bock collection dental casts. All individuals were of known age, sex, and genealogy. Narrow-sense heritability estimates were obtained for LEH presence and count data from all unworn, fully erupted teeth (excluding third molars) using SOLAR (v.8.1.1). Age, sex, and age-sex interaction were included as covariates. Models were re-run with a household effect variable. RESULTS: LEH persists across generations in this study population with moderate, significant heritability estimates for presence in four teeth, and count in four teeth (three teeth were significant for both). When a household effect variable was added, no residual heritability remained for LEH count on any tooth. There was no significant household effect for three of the four teeth that had significant heritability estimates for LEH presence. Age was a significant covariate. Further analyses with birth year data revealed a secular trend toward less LEH. CONCLUSIONS: This study provides evidence for familial risk of LEH (genetic and environmental) that has consequences for the broad use of this skeletal marker of stress. These results have repercussions for archaeological assemblages, or population health studies, where genetic relatives and household groups might be heavily represented

Biology · Enamel hypoplasia · Enamel paint · Heritability · Population · Bone and Dental Protein Studies · Demography · Dental Health and Care Utilization · Dentistry · Forensic Anthropology and Bioarchaeology Studies · Genetics · Medicine

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