Effect of Apolipoprotein E Genotype and Saturated Fat Intake on Plasma Lipids and Myocardial Infarction in the Central Valley of Costa Rica
Bibliographic Data
| ID | 8960598 |
|---|---|
| Authors | Yadong Yang (0009-0004-4810-0606, Harvard University, corresponding author), Edward A Ruiz-Narváez (0000-0002-0339-5824, Harvard University, corresponding author), Peter Kraft (0000-0002-4472-8103, Harvard University, corresponding author), Hannia Campos (0000-0001-9964-6802, Harvard University, corresponding author) |
| Year | 2007 |
| Volume | 79 |
| Issue | 6 |
| Pages | 637-647 |
| Publication date | 2007-12-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 0018-7143 • E-ISSN: 1534-6617 |
| Publisher | Human Biology (The International Journal of Population Biology and Genetics) (PUBLISHER) |
| DOI | 10.1353/hub.2008.0010 |
| PMID | 18494374 |
| OpenAlex | W1630952711 |
| Language | EN |
| Citations received | 2 |
| References cited | 1 |
We assessed the effect of APOE polymorphisms -491 A/T, C112R (APOE*4), and R158C (APOE*2) and saturated fat intake on plasma lipid levels and risk of myocardial infarction (MI) in 1,927 case subjects and 1,927 population-based control subjects matched for age, sex, and residence, all living in the Central Valley of Costa Rica. A significant gene-diet interaction (p = 0.0157) was observed. High saturated fat intake was associated with a 49% increased risk of MI (OR = 1.49; 95% CI, 1.16-1.92) among wildtype subjects. In contrast, high saturated fat intake was associated with a 2.2-fold increased risk of MI among carriers of APOE*2 (OR = 3.17; 95% CI, 1.58-6.36) and with a 1.6-fold increase among carriers of the -491T and APOE*4 variants together (OR = 2.59; 95% CI, 1.38-4.87). Consistently, a high fat diet elicited a greater response in LDL cholesterol among carriers of APOE*2 (+ 17%) and APOE*4 (+ 14%) compared to noncarriers (+6%). The frequency of APOE variants was similar in case and control subjects, although APOE*4 homozygotes were at increased risk of MI compared to noncarriers (OR = 2.26; 95% CI, 1.03-4.98). This study supports the hypothesis that the APOE*2 and APOE*4 variants increase susceptibility to MI in the presence of high saturated fat and could explain inconsistent findings on the effects of these variants on MI in various populations
Allele · Apolipoprotein B · Apolipoprotein E · Biology · Cholesterol · Disease · Gene · Genotype · Myocardial infarction · Saturated fat · Diabetes, Cardiovascular Risks, and Lipoproteins · Endocrinology · Genetic Associations and Epidemiology · Genetics · Internal Medicine · Lipoproteins and Cardiovascular Health · Medicine
| Highly cited | No |
|---|