The Transformation of Utilities for Health States Worse Than Death
Consequences for the Estimation of EQ-5D Value Sets
Bibliographic Data
| ID | 9102443 |
|---|---|
| Authors | Leida M Lamers (Erasmus MC, corresponding author) |
| Year | 2007 |
| Volume | 45 |
| Issue | 3 |
| Pages | 238-244 |
| Publication date | 2007-03-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Medical Care (JOURNAL) |
| Journal identifiers | ISSN: 0025-7079 • E-ISSN: 1537-1948 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/01.mlr.0000252166.76255.68 |
| PMID | 17304081 |
| OpenAlex | W2015543427 |
| Language | EN |
| Citations received | 13 |
| References cited | 13 |
BACKGROUND: Utilities for health are measured on an interval scale, where 1 refers to full health and 0 refers to death. No theoretical lower boundary on the utilities for states worse than death exists. As a consequence, negative values receive greater weight in the calculation of mean utilities. To avoid this, negative values often are bound at -1. OBJECTIVE: The objective of this study was to compare the effect of 3 methods to bound negative values at -1 on the estimation of EQ-5D value sets: truncation, monotonic, and linear transformation. METHOD: Data of the Dutch EQ-5D valuation study were used. A total of 298 respondents directly valued 17 EQ-5D health states using the time trade-off (TTO) method. Random effects regression analysis was used to interpolate TTO values for all possible EQ-5D states. In the regression analysis the dependent variable is 1 minus the TTO value and the independent variables describe the health state. Two widely used models to estimate EQ-5D value were applied after truncation of negative values and monotonic and linear transformation of negative values. Both models also were estimated on medians. RESULTS: Truncation of negative values gave the largest mean absolute error (MAE); the linear transformation resulted in the smallest MAE. When medians were used for estimation, the MAEs were comparable with the estimation on means. CONCLUSION: The choice of a method to bound negative values is arbitrary and affects the resulting value set. For the estimation of EQ-5D value sets from a societal perspective the use of medians should be considered
Econometrics · EQ-5D · Linear regression · Monotonic function · Regression analysis · Statistics · Transformation (genetics) · Truncation (statistics) · Value (mathematics) · Global Health Care Issues · Health Systems, Economic Evaluations, Quality of Life · Healthcare Policy and Management · Mathematics · Medicine
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From a different angle
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| Unique citing works | 13 |
|---|---|
| Citations per year | 0,72 |
| Citation span | 2008 - 2024 (17) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 12 |