Very Low Birth Weight Hospital Volume and Mortality

An Instrumental Variables Approach

Bibliographic Data

ID9103005
AuthorsGeorge L Wehby (0000-0001-7784-9908, University of Iowa, corresponding author), Fred Ullrich (0000-0003-0726-1708, University of Iowa, corresponding author), Yang Xie (0000-0002-8864-960X), Yang Yang Xie (0000-0001-5253-909X, Merck & Co., Inc., Rahway, NJ, USA (United States))
Year2012
Volume50
Issue8
Pages714-721
Publication date2012-08-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueMedical Care (JOURNAL)
Journal identifiersISSN: 0025-7079 • E-ISSN: 1537-1948
PublisherOvid Technologies (Wolters Kluwer Health) (PUBLISHER)
DOI10.1097/mlr.0b013e31824e32cf
PMID22437621
PMCIDPMC3388172
OpenAlexW1967346828
LanguageEN
Citations received2
References cited17

BACKGROUND: Previous studies of very low birth weight (VLBW) hospital volume effects on in-hospital mortality have used standard risk-adjusted models that only account for observable confounders but not for self-selection bias due to unobservable confounders. OBJECTIVE: To assess the effects of hospital volume of VLBW infants on in-hospital mortality while explicitly accounting for unobservable confounders and self-selection bias using an instrumental variables (IV) model. METHODS: The sample includes 4553 VLBW infants born in 63 hospitals in 2000-2004 in New Jersey. We use IV analysis with the differences between the patient's distances to the nearest low ( 100 VLBW infants annually)-volume hospitals as instruments. We evaluate several volume measures and adjusted for observable infant and hospital characteristics. RESULTS: We find beneficial volume effects on survival that are significantly underestimated in classic risk-adjusted models, under which low and moderate volumes compared with high volumes increase mortality odds by 1.8 and 1.88 times, respectively (risk ratios of 1.4 and 1.5, respectively). However, using the IV approach, we find that low and moderate volumes increase mortality odds by 5.42 and 3.51 times, respectively (risk ratios of 2.76 and 2.21, respectively). These findings suggest unobservable confounders that increase the selection of infants at a greater mortality risk into higher-volume hospitals. CONCLUSIONS: Accounting for unobserved self-selection bias reveals large survival benefits from delivering and treating VLBW infants at high-volume hospitals. This supports policies regionalizing the delivery and care for pregnancies at risk for VLBW at high-volume hospitals

Low birth weight · Pregnancy · Volume (thermodynamics) · Emergency Medicine · Gestational Diabetes Research and Management · Global Maternal and Child Health · Medicine · Neonatal Respiratory Health Research

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