Muin J Khoury
Biographic Data
| ID | 5485125 |
|---|---|
| NAME | Muin J Khoury |
| GIVEN NAMES | Muin J |
| FAMILY NAME | Khoury |
| SIGNATURE | KHOURY M J |
| AFFILIATIONS | Office of Public Health Genomics |
| ORCID | 0000-0002-9887-443X |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 47 |
| AUTHOR COUNT | 14 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1983 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 3 |
A cross-sectional study of psychological safety: Barriers and facilitators in a non-western clinical setting
PURPOSE: Psychological safety is a cornerstone of effective clinical learning. While extensively studied in Western contexts, little is known about its barriers and facilitators, as well as its relationship to feedback-seeking and competence development in high power-distance, non-Western residency programs. This study explored barriers and facilitators of psychological safety and examined its associations with residents' feedback-seeking behavio…
Understanding the Process of Family Cancer History Collection and Health Information Seeking
Problem Addressed: To better understand the factors associated with family cancer history (FCH) information and cancer information seeking, we model the process an individual undergoes when assessing whether to gather FCH and seek cancer information and compare models by sociodemographics and family history of cancer. We used cross-sectional data from the Health Information National Trends Survey (HINTS 5, Cycle 2) and variables (e.g., emotion an…
Leveraging Implementation Science to Address Health Disparities in Genomic Medicine: Examples from the Field
The integration of genomic data into screening, prevention, diagnosis, and treatment for clinical and public health practices has been slow and challenging. Implementation science can be applied in tackling the barriers and challenges as well as exploring opportunities and best practices for integrating genomic data into routine clinical and public health practice.In this article, we define the state of disparities in genomic medicine and focus p…
Leveraging Implementation Science to Address Health Disparities in Genomic Medicine: Examples from the Field
The integration of genomic data into screening, prevention, diagnosis, and treatment for clinical and public health practices has been slow and challenging. Implementation science can be applied in tackling the barriers and challenges as well as exploring opportunities and best practices for integrating genomic data into routine clinical and public health practice. In this article, we define the state of disparities in genomic medicine and f…
Precision Public Health for the Era of Precision Medicine
Beyond Base Pairs to Bedside: A Population Perspective on How Genomics Can Improve Health
A decade after the sequencing of the human genome, the National Human Genome Research Institute announced a strategic plan for genomic medicine. It calls for evaluating the structure and biology of genomes, understanding the biology of disease, advancing the science of medicine, and improving the effectiveness of health care. Fulfilling the promise of genomics urgently requires a population perspective to complement the bench-to-bedside model of …
National Institutes of Health Approaches to Dissemination and Implementation Science: Current and Future Directions
To address the vast gap between current knowledge and practice in the area of dissemination and implementation research, we address terminology, provide examples of successful applications of this research, discuss key sources of support, and highlight directions and opportunities for future advances. There is a need for research testing approaches to scaling up and sustaining effective interventions, and we propose that further advances in the f…
Public Awareness and Use of Direct-to-Consumer Genetic Tests: Results From 3 State Population-Based Surveys, 2006
We conducted population-based surveys on direct-to-consumer nutrigenomic testing in Michigan, Oregon, and Utah as part of the 2006 Behavioral Risk Factor Surveillance System. Awareness of the tests was highest in Oregon (24.4%) and lowest in Michigan (7.6%). Predictors of awareness were more education, higher income, and increasing age, except among those 65 years or older. Less than 1% had used a health-related direct-to-consumer genetic test. P…
The surveillance of birth defects: The usefulness of the revised US standard birth certificate
To assess the sensitivity and positive predictive value of birth defects reported on the 1989 revision of the US Standard Birth Certificate, a population of 76,862 Atlanta-area births during 1989 and 1990 was used as the basis for comparing 771 birth certificates that reported birth defects with 2428 live-born infant records in a birth defects registry that uses multiple sources of case ascertainment. Only 14% of birth defects in the registry rec…
From genes to public health: The applications of genetic technology in disease prevention. Genetics Working Group
OBJECTIVES: With advances in the Human Genome Project, the implications of genetic technology in disease prevention should be assessed. METHODS: The paradigm suggested in The Future of Public Health--assessment, policy development, and assurance--was used to examine the continuum from genetic technology to public health practice. RESULTS: First, important public health functions are to (1) assess the impact of genes and their interactions with mo…
First-trimester anesthesia exposure and the risk of central nervous system defects: A population-based case-control study
OBJECTIVES. Although up to 2% of women undergo surgery during pregnancy, teratogenic effects of general anesthesia have not been adequately studied. Recently, an association between first-trimester operations and central nervous system defects has been described. This issue was explored in a population-based case-control study. METHODS. Case patients included live-born and stillborn infants with central nervous system defects born to residents of…
Maternal cigarette smoking and oral clefts: A population-based study
Analyses of 1984 data from the Maryland Birth Defects Reporting and Information System indicate that mothers of infants with oral clefts (cleft lip with or without cleft palate; and cleft palate) smoked more during pregnancy than mothers of infants with other defects (odds ratio OR of 2.56 and 2.39, respectively). There was a dose-response relation between the daily amount smoked and the risk of clefting. Adjustment for available confounding vari…
Epidemiologic evaluation of screening for risk factors: Application to genetic screening
To assess the usefulness of screening for risk factors, we derived arithmetic relationships between screening parameters (sensitivity, specificity, and positive predictive value PPV) and risk factor frequency, disease frequency and relative risk. We evaluated these relationships in the special case of genetic markers and disease susceptibility. It can be shown that even in the face of very large relative risks, sensitivity and positive predictive…
Maternal factors in dizygotic twinning: Evidence from interracial crosses
In the USA, Blacks have been shown to have a higher incidence of DZ twinning than Whites. We studied maternal and paternal race determinants of the rates of like-sex and unlike-sex twinning using US live-birth certificate data for 1973-78. After adjustment was made for father's race, Black mothers had a higher rate of unlike-sex twinning than White mothers (odds ratio, OR = 1.74, P less than 10(-8]. This maternal race effect persisted after furth…
National Institutes of Health Approaches to Dissemination and Implementation Science: Current and Future Directions
To address the vast gap between current knowledge and practice in the area of dissemination and implementation research, we address terminology, provide examples of successful applications of this research, discuss key sources of support, and highlight directions and opportunities for future advances. There is a need for research testing approaches to scaling up and sustaining effective interventions, and we propose that further advances in the f…
The surveillance of birth defects: The usefulness of the revised US standard birth certificate
To assess the sensitivity and positive predictive value of birth defects reported on the 1989 revision of the US Standard Birth Certificate, a population of 76,862 Atlanta-area births during 1989 and 1990 was used as the basis for comparing 771 birth certificates that reported birth defects with 2428 live-born infant records in a birth defects registry that uses multiple sources of case ascertainment. Only 14% of birth defects in the registry rec…
From genes to public health: The applications of genetic technology in disease prevention. Genetics Working Group
OBJECTIVES: With advances in the Human Genome Project, the implications of genetic technology in disease prevention should be assessed. METHODS: The paradigm suggested in The Future of Public Health--assessment, policy development, and assurance--was used to examine the continuum from genetic technology to public health practice. RESULTS: First, important public health functions are to (1) assess the impact of genes and their interactions with mo…
Maternal cigarette smoking and oral clefts: A population-based study
Analyses of 1984 data from the Maryland Birth Defects Reporting and Information System indicate that mothers of infants with oral clefts (cleft lip with or without cleft palate; and cleft palate) smoked more during pregnancy than mothers of infants with other defects (odds ratio OR of 2.56 and 2.39, respectively). There was a dose-response relation between the daily amount smoked and the risk of clefting. Adjustment for available confounding vari…
Beyond Base Pairs to Bedside: A Population Perspective on How Genomics Can Improve Health
A decade after the sequencing of the human genome, the National Human Genome Research Institute announced a strategic plan for genomic medicine. It calls for evaluating the structure and biology of genomes, understanding the biology of disease, advancing the science of medicine, and improving the effectiveness of health care. Fulfilling the promise of genomics urgently requires a population perspective to complement the bench-to-bedside model of …
Epidemiologic evaluation of screening for risk factors: Application to genetic screening
To assess the usefulness of screening for risk factors, we derived arithmetic relationships between screening parameters (sensitivity, specificity, and positive predictive value PPV) and risk factor frequency, disease frequency and relative risk. We evaluated these relationships in the special case of genetic markers and disease susceptibility. It can be shown that even in the face of very large relative risks, sensitivity and positive predictive…
Maternal factors in dizygotic twinning: Evidence from interracial crosses
In the USA, Blacks have been shown to have a higher incidence of DZ twinning than Whites. We studied maternal and paternal race determinants of the rates of like-sex and unlike-sex twinning using US live-birth certificate data for 1973-78. After adjustment was made for father's race, Black mothers had a higher rate of unlike-sex twinning than White mothers (odds ratio, OR = 1.74, P less than 10(-8]. This maternal race effect persisted after furth…
Epidemiologic evaluation of screening for risk factors: Application to genetic screening
To assess the usefulness of screening for risk factors, we derived arithmetic relationships between screening parameters (sensitivity, specificity, and positive predictive value PPV) and risk factor frequency, disease frequency and relative risk. We evaluated these relationships in the special case of genetic markers and disease susceptibility. It can be shown that even in the face of very large relative risks, sensitivity and positive predictive…
Maternal cigarette smoking and oral clefts: A population-based study
Analyses of 1984 data from the Maryland Birth Defects Reporting and Information System indicate that mothers of infants with oral clefts (cleft lip with or without cleft palate; and cleft palate) smoked more during pregnancy than mothers of infants with other defects (odds ratio OR of 2.56 and 2.39, respectively). There was a dose-response relation between the daily amount smoked and the risk of clefting. Adjustment for available confounding vari…
First-trimester anesthesia exposure and the risk of central nervous system defects: A population-based case-control study
OBJECTIVES. Although up to 2% of women undergo surgery during pregnancy, teratogenic effects of general anesthesia have not been adequately studied. Recently, an association between first-trimester operations and central nervous system defects has been described. This issue was explored in a population-based case-control study. METHODS. Case patients included live-born and stillborn infants with central nervous system defects born to residents of…
The surveillance of birth defects: The usefulness of the revised US standard birth certificate
To assess the sensitivity and positive predictive value of birth defects reported on the 1989 revision of the US Standard Birth Certificate, a population of 76,862 Atlanta-area births during 1989 and 1990 was used as the basis for comparing 771 birth certificates that reported birth defects with 2428 live-born infant records in a birth defects registry that uses multiple sources of case ascertainment. Only 14% of birth defects in the registry rec…
From genes to public health: The applications of genetic technology in disease prevention. Genetics Working Group
OBJECTIVES: With advances in the Human Genome Project, the implications of genetic technology in disease prevention should be assessed. METHODS: The paradigm suggested in The Future of Public Health--assessment, policy development, and assurance--was used to examine the continuum from genetic technology to public health practice. RESULTS: First, important public health functions are to (1) assess the impact of genes and their interactions with mo…
Public Awareness and Use of Direct-to-Consumer Genetic Tests: Results From 3 State Population-Based Surveys, 2006
We conducted population-based surveys on direct-to-consumer nutrigenomic testing in Michigan, Oregon, and Utah as part of the 2006 Behavioral Risk Factor Surveillance System. Awareness of the tests was highest in Oregon (24.4%) and lowest in Michigan (7.6%). Predictors of awareness were more education, higher income, and increasing age, except among those 65 years or older. Less than 1% had used a health-related direct-to-consumer genetic test. P…
Beyond Base Pairs to Bedside: A Population Perspective on How Genomics Can Improve Health
A decade after the sequencing of the human genome, the National Human Genome Research Institute announced a strategic plan for genomic medicine. It calls for evaluating the structure and biology of genomes, understanding the biology of disease, advancing the science of medicine, and improving the effectiveness of health care. Fulfilling the promise of genomics urgently requires a population perspective to complement the bench-to-bedside model of …
National Institutes of Health Approaches to Dissemination and Implementation Science: Current and Future Directions
To address the vast gap between current knowledge and practice in the area of dissemination and implementation research, we address terminology, provide examples of successful applications of this research, discuss key sources of support, and highlight directions and opportunities for future advances. There is a need for research testing approaches to scaling up and sustaining effective interventions, and we propose that further advances in the f…
Precision Public Health for the Era of Precision Medicine
Leveraging Implementation Science to Address Health Disparities in Genomic Medicine: Examples from the Field
The integration of genomic data into screening, prevention, diagnosis, and treatment for clinical and public health practices has been slow and challenging. Implementation science can be applied in tackling the barriers and challenges as well as exploring opportunities and best practices for integrating genomic data into routine clinical and public health practice.In this article, we define the state of disparities in genomic medicine and focus p…
Leveraging Implementation Science to Address Health Disparities in Genomic Medicine: Examples from the Field
The integration of genomic data into screening, prevention, diagnosis, and treatment for clinical and public health practices has been slow and challenging. Implementation science can be applied in tackling the barriers and challenges as well as exploring opportunities and best practices for integrating genomic data into routine clinical and public health practice. In this article, we define the state of disparities in genomic medicine and f…
Understanding the Process of Family Cancer History Collection and Health Information Seeking
Problem Addressed: To better understand the factors associated with family cancer history (FCH) information and cancer information seeking, we model the process an individual undergoes when assessing whether to gather FCH and seek cancer information and compare models by sociodemographics and family history of cancer. We used cross-sectional data from the Health Information National Trends Survey (HINTS 5, Cycle 2) and variables (e.g., emotion an…
A cross-sectional study of psychological safety: Barriers and facilitators in a non-western clinical setting
PURPOSE: Psychological safety is a cornerstone of effective clinical learning. While extensively studied in Western contexts, little is known about its barriers and facilitators, as well as its relationship to feedback-seeking and competence development in high power-distance, non-Western residency programs. This study explored barriers and facilitators of psychological safety and examined its associations with residents' feedback-seeking behavio…
Medicine (13 works) · Biology (9 works) · BRCA gene mutations in cancer (7 works) · Environmental health (7 works) · Population (7 works) · Computer Science (6 works) · Internal Medicine (6 works) · Nutrition, Genetics, and Disease (5 works) · Data science (4 works) · Demography (4 works)