Ludger Tebartz van Elst
Biographic Data
| ID | 6551202 |
|---|---|
| NAME | Ludger Tebartz van Elst |
| GIVEN NAMES | Ludger Tebartz |
| FAMILY NAME | van Elst |
| SIGNATURE | VAN ELST L T |
| AFFILIATIONS | University Medical Center Freiburg |
| ORCID | 0000-0002-2274-5447 |
| VERIFIED | Yes |
| TOTAL WORKS | 21 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 21 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2015 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 0 |
Multi-voxel MR-spectroscopy signatures and associations with EEG network hyperexcitability and clinical symptomatology in borderline personality disorder
While no robust group differences emerged, mixed-models using continuous predictors linked higher Glx ratios in nucleus accumbens/cACC to IRDA/IRTA and higher striatal tCr/tNAA to BPD symptom severity and neurocognitive performance. These exploratory multimodal signatures point to cortico-striato-limbic mechanisms in BPD and should be confirmed in larger samples
Humor in ASD
Autism spectrum disorders (ASD) are often associated with humorlessness. The present study aimed to separate potential differences in humor appreciation from text comprehension difficulties. Twenty-three adults with ASD and 23 neurotypical adults (age: 18–72 years) read four types of texts: jokes, non-funny revision texts (requiring an incongruity resolution), straightforward and incoherent control texts. Funniness ratings, comprehension accuracy…
Processing of prosodic cues of uncertainty in autistic and non-autistic adults
In future work, we would like to further investigate the interaction of all three cues and uncertainty perception. It would be interesting to further vary the duration of the pause and also to use different types of fillers. From a developmental perspective, uncertainty perception should also be investigated in children and adolescents with ASD
An German Short-Version of the “Sensory Perception Quotient” for Adults With Autism Spectrum Disorder
Sensory features in autism spectrum disorder (ASD) have received increasing interest in clinical work and research during the recent years. With the Sensory Perception Quotient (SPQ), Tavasolli and colleagues have produced a self-rating scale for adults with ASD that measures sensory hyper-sensitivity in different sensory modalities, without also tapping cognitive or motivational aspects that precede or follow autistic sensory experiences. Here, …
A Neglected Topic in Neuroscience
Functional magnetic resonance imaging (fMRI) studies report impaired functional correlates of cognition and emotion in mental disorders. The validity of preexisting studies needs to be confirmed through replication studies, which there is a lack of. So far, most replication studies have been conducted on non-patients (NP) and primarily investigated cognitive and motor tasks. To fill this gap, we conducted the first fMRI replication study to inves…
Novel Antineuronal Autoantibodies With Somatodendritic Staining Pattern in a Patient With Autoimmune Psychosis
The patient probably suffered from autoantibody-associated autoimmune psychosis. The special features of the case were that the patient (1) presented with mostly inconspicuous basic diagnostics, except for the altered EEG in combination with the detection of CSF autoantibodies directed against a currently unknown epitope, (2) experienced an isolated and long-lasting psychotic course, and (3) had pre-existing autism spectrum disorder. The detectio…
Comorbidity Matters
Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) represent two common neurodevelopmental disorders with considerable co-occurrence. Their comorbidity (ASD + ADHD) has been included in the latest diagnostic guidelines (DSM-V, 2013). The present study focuses on social visual attention that i) is a main aspect of social attention reflecting social cognition and ii) its atypicalities have been suggested as a potenti…
Probable Autoimmune Depression in a Patient With Multiple Sclerosis and Antineuronal Antibodies
The present patient suffered from a probable "autoimmune depression" in the context of newly diagnosed multiple sclerosis with typical MRI and CSF pathologies, alongside mild concomitant latent systemic autoimmune process (with high-titer ANAs and lymphopenia) and unknown antineuronal antibodies. The case report illustrates that a depressive syndrome suggestive of primary idiopathic depressive disorder may be associated with an autoimmune brain i…
Social Visual Perception Under the Eye of Bayesian Theories in Autism Spectrum Disorder Using Advanced Modeling of Spatial and Temporal Parameters
Social interaction in individuals with Autism Spectrum Disorder (ASD) is characterized by qualitative impairments that highly impact quality of life. Bayesian theories in ASD frame an understanding of underlying mechanisms suggesting atypicalities in the evaluation of probabilistic links within the perceptual environment of the affected individual. To address these theories, the present study explores the applicability of an innovative Bayesian f…
Anti-N-Methyl-D-Aspartate-Receptor Encephalitis
Anti-inflammatory treatment led to almost full recovery with persistent disappearance of catatonic symptoms; however, a dysexecutive syndrome led to ongoing relevant problems with good response to low-dose atypical neuroleptics and CBT. The patient had persistent EEG alterations that indicated continuing neuronal network instability. Therefore, the case demonstrates the importance of multidisciplinary outpatient treatment following acute therapy …
White Matter Abnormalities in the Corpus Callosum in Acute and Recovered Anorexia Nervosa Patients—A Diffusion Tensor Imaging Study
Objective: Severe malnutrition in patients with anorexia nervosa (AN) as well as possible trait-related aberrations lead to pronounced structural brain changes whose reversibility after recovery is currently unclear. Previous diffusion tensor imaging (DTI) studies investigating white matter (WM) microstructure alterations in AN are inconsistent. Methods: In this so far largest DTI study in adults, we investigated 33 AN patients, 20 recovered (REC…
Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid
Background: Organic psychiatric disorders can be caused by immunological disorders, such as autoimmune encephalitis or systemic lupus erythematosus (SLE). SLE can affect most organs, as well as the central nervous system (CNS). In this paper, we describe a patient with an isolated psychiatric syndrome in the context of SLE and discuss the role of antibody detection in the cerebrospinal fluid (CSF). Case presentation: The 22-year-old German male h…
Inferior Frontal Gyrus Volume Loss Distinguishes Between Autism and (Comorbid) Attention-Deficit/Hyperactivity Disorder—A FreeSurfer Analysis in Children
Objective: Autism spectrum (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental disorders with a high rate of comorbidity. To date, diagnosis is based on clinical presentation and distinct reliable biomarkers have been identified neither for ASD nor ADHD. Most previous neuroimaging studies investigated ASD and ADHD separately. Method: To address the question of structural brain differences between ASD and ADHD, we perf…
Myoclonic Jerks and Schizophreniform Syndrome
Background: Schizophreniform syndromes can be divided into primary idiopathic forms as well as different secondary organic subgroups (e.g., paraepileptic, epileptic, immunological, or degenerative). Secondary epileptic explanatory approaches have often been discussed in the past, due to the high rates of electroencephalography (EEG) alterations in patients with schizophrenia. In particular, temporal lobe epilepsy is known to be associated with sc…
Disease, Human Norm, and Human Diversity in Neuropsychiatry
In everyday language as well as scientific language, there are but few terms and concepts with such a comprehensive negative meaning and connotation as the term 'dis-ease.’ Disease is a universal evil. Nobody wants disease and everybody would agree that disease should be defeated and eradicated. But what if disease strikes one’s own body and mind? What if the imperative of disease eradication targets properties of the body which is me? This is th…
Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies
SREAT can mimic typical symptoms of schizophreniform syndromes. The increased titer of antithyroid peroxidase antibodies in combination with the EEG slowing, blood-brain barrier dysfunction, and the cMRI alterations were the basis for suspecting an immunological cause in our patient. Chronic delusions, olfactory hallucinations, and cognitive deficits were successfully treated with corticosteroids. The occurrence of secondary immunological forms o…
Schizophrenia Associated with Epileptiform Discharges without Seizures Successfully Treated with Levetiracetam
The schizophrenia-like symptoms associated with epileptiform discharges but not overt seizures and the good response to antiepileptic treatment could be interpreted in the context of a (para)epileptic pathomechanism. The EEG alterations might be due to a polygenetic effect due to different genes. Mild immunological mechanisms in the framework of ulcerative colitis and increased ANA titers might have supported the network instability. This case re…
Plasmapheresis Responsive Rapid Onset Dementia with Predominantly Frontal Dysfunction in the Context of Hashimoto’s Encephalopathy
This case report reveals that (1) HE can mimic rapid onset dementia with predominantly frontal dysfunction; (2) this syndrome can be successfully treated in the context of HE; and (3) plasmapheresis can be effective in such a disease constellation. The detection of the immunological causes of rapid onset dementia and other psychiatric syndromes is important because it opens opportunities for new, innovative immunosuppressive treatment options
Alterations in Cerebrospinal Fluid in Patients with Bipolar Syndromes
Bipolar disorder (BD) is a severe and lifelong condition. Primary endogenic polygenetic forms are common. Secondary organic forms have received increasing interest recently due to the detection of immunological encephalopathies that mimic various psychiatric syndromes, including BD. However, only limited data about routine findings of cerebrospinal fluid (CSF) analyses in BD are available. Therefore, we investigated the frequency of alterations i…
Vitamin D Deficiency in Adult Patients with Schizophreniform and Autism Spectrum Syndromes
We found very high rates of 25(OH)vitamin D deficiencies in both patient groups and have discussed whether our findings might be related to alterations in the immunological mechanisms. Irrespective of the possible pathophysiological links between vitamin D deficiency and schizophrenia or autism spectrum disorders, a more frequent measurement of vitamin D levels seems to be justified in these patient groups. Further prospective, controlled, blinde…
Freiheit
Ist Freiheit aus neurowissenschaftlicher Perspektive eine Illusion? In diesem Buch wird gezeigt, dass dies nur dann der Fall ist, wenn Unfreiheit so definiert wird, dass sie entsteht, wenn menschliches Verhalten vom eigenen Körper gesteuert wird. Dementgegen wird ein positives Verständnis von Freiheit entwickelt als Qualität einer Untergruppe von behavioralen Sequenzen. Sie ist als psychobiologische Komplexleistung höherer Lebewesen kein Phänomen…
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Freiheit
Ist Freiheit aus neurowissenschaftlicher Perspektive eine Illusion? In diesem Buch wird gezeigt, dass dies nur dann der Fall ist, wenn Unfreiheit so definiert wird, dass sie entsteht, wenn menschliches Verhalten vom eigenen Körper gesteuert wird. Dementgegen wird ein positives Verständnis von Freiheit entwickelt als Qualität einer Untergruppe von behavioralen Sequenzen. Sie ist als psychobiologische Komplexleistung höherer Lebewesen kein Phänomen…
Alterations in Cerebrospinal Fluid in Patients with Bipolar Syndromes
Bipolar disorder (BD) is a severe and lifelong condition. Primary endogenic polygenetic forms are common. Secondary organic forms have received increasing interest recently due to the detection of immunological encephalopathies that mimic various psychiatric syndromes, including BD. However, only limited data about routine findings of cerebrospinal fluid (CSF) analyses in BD are available. Therefore, we investigated the frequency of alterations i…
Vitamin D Deficiency in Adult Patients with Schizophreniform and Autism Spectrum Syndromes
We found very high rates of 25(OH)vitamin D deficiencies in both patient groups and have discussed whether our findings might be related to alterations in the immunological mechanisms. Irrespective of the possible pathophysiological links between vitamin D deficiency and schizophrenia or autism spectrum disorders, a more frequent measurement of vitamin D levels seems to be justified in these patient groups. Further prospective, controlled, blinde…
Disease, Human Norm, and Human Diversity in Neuropsychiatry
In everyday language as well as scientific language, there are but few terms and concepts with such a comprehensive negative meaning and connotation as the term 'dis-ease.’ Disease is a universal evil. Nobody wants disease and everybody would agree that disease should be defeated and eradicated. But what if disease strikes one’s own body and mind? What if the imperative of disease eradication targets properties of the body which is me? This is th…
Steroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies
SREAT can mimic typical symptoms of schizophreniform syndromes. The increased titer of antithyroid peroxidase antibodies in combination with the EEG slowing, blood-brain barrier dysfunction, and the cMRI alterations were the basis for suspecting an immunological cause in our patient. Chronic delusions, olfactory hallucinations, and cognitive deficits were successfully treated with corticosteroids. The occurrence of secondary immunological forms o…
Schizophrenia Associated with Epileptiform Discharges without Seizures Successfully Treated with Levetiracetam
The schizophrenia-like symptoms associated with epileptiform discharges but not overt seizures and the good response to antiepileptic treatment could be interpreted in the context of a (para)epileptic pathomechanism. The EEG alterations might be due to a polygenetic effect due to different genes. Mild immunological mechanisms in the framework of ulcerative colitis and increased ANA titers might have supported the network instability. This case re…
Plasmapheresis Responsive Rapid Onset Dementia with Predominantly Frontal Dysfunction in the Context of Hashimoto’s Encephalopathy
This case report reveals that (1) HE can mimic rapid onset dementia with predominantly frontal dysfunction; (2) this syndrome can be successfully treated in the context of HE; and (3) plasmapheresis can be effective in such a disease constellation. The detection of the immunological causes of rapid onset dementia and other psychiatric syndromes is important because it opens opportunities for new, innovative immunosuppressive treatment options
Inferior Frontal Gyrus Volume Loss Distinguishes Between Autism and (Comorbid) Attention-Deficit/Hyperactivity Disorder—A FreeSurfer Analysis in Children
Objective: Autism spectrum (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental disorders with a high rate of comorbidity. To date, diagnosis is based on clinical presentation and distinct reliable biomarkers have been identified neither for ASD nor ADHD. Most previous neuroimaging studies investigated ASD and ADHD separately. Method: To address the question of structural brain differences between ASD and ADHD, we perf…
Myoclonic Jerks and Schizophreniform Syndrome
Background: Schizophreniform syndromes can be divided into primary idiopathic forms as well as different secondary organic subgroups (e.g., paraepileptic, epileptic, immunological, or degenerative). Secondary epileptic explanatory approaches have often been discussed in the past, due to the high rates of electroencephalography (EEG) alterations in patients with schizophrenia. In particular, temporal lobe epilepsy is known to be associated with sc…
White Matter Abnormalities in the Corpus Callosum in Acute and Recovered Anorexia Nervosa Patients—A Diffusion Tensor Imaging Study
Objective: Severe malnutrition in patients with anorexia nervosa (AN) as well as possible trait-related aberrations lead to pronounced structural brain changes whose reversibility after recovery is currently unclear. Previous diffusion tensor imaging (DTI) studies investigating white matter (WM) microstructure alterations in AN are inconsistent. Methods: In this so far largest DTI study in adults, we investigated 33 AN patients, 20 recovered (REC…
Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid
Background: Organic psychiatric disorders can be caused by immunological disorders, such as autoimmune encephalitis or systemic lupus erythematosus (SLE). SLE can affect most organs, as well as the central nervous system (CNS). In this paper, we describe a patient with an isolated psychiatric syndrome in the context of SLE and discuss the role of antibody detection in the cerebrospinal fluid (CSF). Case presentation: The 22-year-old German male h…
A Neglected Topic in Neuroscience
Functional magnetic resonance imaging (fMRI) studies report impaired functional correlates of cognition and emotion in mental disorders. The validity of preexisting studies needs to be confirmed through replication studies, which there is a lack of. So far, most replication studies have been conducted on non-patients (NP) and primarily investigated cognitive and motor tasks. To fill this gap, we conducted the first fMRI replication study to inves…
Novel Antineuronal Autoantibodies With Somatodendritic Staining Pattern in a Patient With Autoimmune Psychosis
The patient probably suffered from autoantibody-associated autoimmune psychosis. The special features of the case were that the patient (1) presented with mostly inconspicuous basic diagnostics, except for the altered EEG in combination with the detection of CSF autoantibodies directed against a currently unknown epitope, (2) experienced an isolated and long-lasting psychotic course, and (3) had pre-existing autism spectrum disorder. The detectio…
Comorbidity Matters
Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) represent two common neurodevelopmental disorders with considerable co-occurrence. Their comorbidity (ASD + ADHD) has been included in the latest diagnostic guidelines (DSM-V, 2013). The present study focuses on social visual attention that i) is a main aspect of social attention reflecting social cognition and ii) its atypicalities have been suggested as a potenti…
Probable Autoimmune Depression in a Patient With Multiple Sclerosis and Antineuronal Antibodies
The present patient suffered from a probable "autoimmune depression" in the context of newly diagnosed multiple sclerosis with typical MRI and CSF pathologies, alongside mild concomitant latent systemic autoimmune process (with high-titer ANAs and lymphopenia) and unknown antineuronal antibodies. The case report illustrates that a depressive syndrome suggestive of primary idiopathic depressive disorder may be associated with an autoimmune brain i…
Social Visual Perception Under the Eye of Bayesian Theories in Autism Spectrum Disorder Using Advanced Modeling of Spatial and Temporal Parameters
Social interaction in individuals with Autism Spectrum Disorder (ASD) is characterized by qualitative impairments that highly impact quality of life. Bayesian theories in ASD frame an understanding of underlying mechanisms suggesting atypicalities in the evaluation of probabilistic links within the perceptual environment of the affected individual. To address these theories, the present study explores the applicability of an innovative Bayesian f…
Anti-N-Methyl-D-Aspartate-Receptor Encephalitis
Anti-inflammatory treatment led to almost full recovery with persistent disappearance of catatonic symptoms; however, a dysexecutive syndrome led to ongoing relevant problems with good response to low-dose atypical neuroleptics and CBT. The patient had persistent EEG alterations that indicated continuing neuronal network instability. Therefore, the case demonstrates the importance of multidisciplinary outpatient treatment following acute therapy …
An German Short-Version of the “Sensory Perception Quotient” for Adults With Autism Spectrum Disorder
Sensory features in autism spectrum disorder (ASD) have received increasing interest in clinical work and research during the recent years. With the Sensory Perception Quotient (SPQ), Tavasolli and colleagues have produced a self-rating scale for adults with ASD that measures sensory hyper-sensitivity in different sensory modalities, without also tapping cognitive or motivational aspects that precede or follow autistic sensory experiences. Here, …
Processing of prosodic cues of uncertainty in autistic and non-autistic adults
In future work, we would like to further investigate the interaction of all three cues and uncertainty perception. It would be interesting to further vary the duration of the pause and also to use different types of fillers. From a developmental perspective, uncertainty perception should also be investigated in children and adolescents with ASD
Humor in ASD
Autism spectrum disorders (ASD) are often associated with humorlessness. The present study aimed to separate potential differences in humor appreciation from text comprehension difficulties. Twenty-three adults with ASD and 23 neurotypical adults (age: 18–72 years) read four types of texts: jokes, non-funny revision texts (requiring an incongruity resolution), straightforward and incoherent control texts. Funniness ratings, comprehension accuracy…
Multi-voxel MR-spectroscopy signatures and associations with EEG network hyperexcitability and clinical symptomatology in borderline personality disorder
While no robust group differences emerged, mixed-models using continuous predictors linked higher Glx ratios in nucleus accumbens/cACC to IRDA/IRTA and higher striatal tCr/tNAA to BPD symptom severity and neurocognitive performance. These exploratory multimodal signatures point to cortico-striato-limbic mechanisms in BPD and should be confirmed in larger samples
Medicine (18 works) · Psychology (14 works) · Psychiatry (13 works) · Autoimmune Neurological Disorders and Treatments (7 works) · Internal Medicine (7 works) · Autism (6 works) · Audiology (5 works) · Autism Spectrum Disorder Research (5 works) · Cognitive psychology (5 works) · Obsessive-Compulsive Spectrum Disorders (5 works)