M Luiza Petzl‐erler
Biographic Data
| ID | 77969 |
|---|---|
| NAME | M Luiza Petzl‐erler |
| GIVEN NAMES | M Luiza |
| FAMILY NAME | Petzl‐erler |
| SIGNATURE | ERLER M L P |
| AFFILIATIONS | Universidade Federal do Paraná |
| ORCID | 0000-0002-0345-5276 |
| VERIFIED | Yes |
| TOTAL WORKS | 24 |
| TOTAL CITATIONS | 48 |
| AUTHOR COUNT | 24 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1997 |
| LATEST PUBLICATION YEAR | 2016 |
| H-INDEX | 3 |
Variability of innate immune system genes in Native A merican populations—relationship with history and epidemiology
OBJECTIVES: The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. MATERIALS AND METHODS: We investigated heterozygozities and patterns …
Genetic evidence for two founding populations of the Americas
Reconstructing Native American population history
Stability or variation? Patterns of lactase gene and its enhancer region distributions in Brazilian Amerindians
Lactase persistence (LP) is the phenotypic trait in which lactase secretion is maintained during adulthood. LP is due to mutations in the LCT enhancer region, located 14‐kb upstream of the gene. In Europeans, the −13910*T allele is associated with LP. In Africans this allele is rare while other mutations in this same region were related to LP. The LCT is highly polymorphic in human populations, but so far Brazilian Amerindians had not been invest…
Variability of the BCHE gene in Amerindians from Paraná, Brazil
Despite the geographical coexistence throughout their dispersion, each of these two Amerindian groups retains a high degree of genetic identity, probably maintained by cultural and social isolation
Dopamine receptor D4 allele distribution in Amerindians: A reflection of past behavior differences
The DRD4 variable number of tandem repeats (VNTR) allele distribution of 172 Guarani (Kaiowá and Ñandeva subgroups) and Kaingang Brazilian Amerindians is reported. These results are integrated with those previously obtained for this ethnic group. Allele frequencies for the three populations are within the interval observed for 15 other Native American populations and show intermediate values between those observed in Amazonia and Patagonia. Signi…
Linkage disequilibrium patterns and genetic structure of Amerindian and non‐Amerindian Brazilian populations revealed by long‐range X‐STR markers
The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the …
Geographic Patterns of Genome Admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for…
Mitochondrial Population Genomics Supports a Single Pre-Clovis Origin with a Coastal Route for the Peopling of the Americas
Y‐STR analysis in Brazilian and South Amerindian populations
A sample of 203 Brazilian males from Rio Grande do Sul (RS), the Brazilian southernmost state, was typed for 11 Y‐STR markers (DYS19, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, and DYS439). We also typed 42 individuals from two South Amerindian tribes (Kaingang and Guarani) to use the data as parental Amerindian contribution to our analyses. Gene and haplotypic diversities were estimated, with the South Amerindian samples…
Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower gen…
The β‐globin gene cluster distribution revisited—Patterns in Native American populations
New frequencies for the β‐globin gene cluster haplotypes are presented for the Aché ( N = 82 individuals), Guarani ( N = 76), and Kaingang ( N = 54), three Native South American populations that live in an area between parallels 20°S and 30°S not covered by previous studies at this locus. The haplotype frequencies obtained for the three populations are within the interval observed for 28 other Native American populations. The Aché show much less …
Cystic Fibrosis Gene Variability in Two Southern Brazilian Amerindian Populations: Analysis of the ΔF508 Mutation and the KM19 and XV2C Haplotypes
The frequencies of the deltaF508 deletion, the most common cystic fibrosis mutation in Europeans and European-derived populations, and the XV2C and KM19 restriction fragment length polymorphisms that are tightly linked to the CFTR locus vary among populations. To determine the distribution of these extragenic markers and of the deltaF508 mutation, we analyzed 326 chromosomes of individuals from two South American Indian populations, the Guarani a…
Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil
A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS-I), and a fraction of them was also studied for seven biallelic Y-chromosome polymorphisms. Nineteen HVS-I lineages were detected, which showed distinct distributions in the two tribes. The G ST value obtained with the mtDNA data is about 5 times highe…
Geography influences microsatellite polymorphism diversity in Amerindians
Data related to 15 short tandem repeat polymorphisms (STRPs) are reported for four South American Indian populations, and integrated with previous Brazilian Indian results. Overall heterozygosities varied significantly among groups (Kruskal-Wallis test, P = 0.002). The lowest levels of heterozygosity were observed in the Ache, Ayoreo, and Surui, an expected finding considering their isolation and ethnohistory. Genetic distance and gene diversity …
Human T-cell lymphotropic virus type II in Guaraní Indians, Southern Brazil
Human T-cell lymphotropic virus type II (HTLV-II) is found in many New World Indian groups on the American continent. In Brazil, HTLV-II has been found among urban residents and Indians in the Amazon region, in the North. Guaraní Indians in the South of Brazil were studied for HTLV-I/II infection. Among 52 individuals, three (5.76%) showed positive anti-HTLV-II antibodies (enzyme-linked immunosorbent assay and Western blot). This preliminary repo…
Y-Chromosome Evidence for Differing Ancient Demographic Histories in the Americas
Demographic and Genetic Structures of Two Partially Isolated Communities of Santa Catarina Island, Southern Brazil
The objectives of this study were to analyze the population structure and genetic variability of two communities, Costa da Lagoa (CLG) and São João do Rio Vermelho (SJRV), located on Santa Catarina Island in southern Brazil. The two populations descend from Azores Archipelago immigrants (Portuguese), with a minor contribution of sub-Saharan Africans and Amerindians. To estimate the relative contribution of the different ethnic groups to the curre…
Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians
Polymorphisms at the TP53 , cytochrome P‐450 ( CYP ), and glutathione S‐transferase ( GST ) genes are related to cancer susceptibility and present high diversity in allele frequencies among ethnic groups. This study concerns the CYP2E1 , GSTM1 , and GSTT1 polymorphisms in seven Amerindian populations (Xavante, Guarani, Aché, Wai Wai, Zoró, Surui, and Gavião). Polymorphic sites at CYP1A1 and TP53 were also studied in the Aché and Guarani tribes an…
Alu insertions versus blood group plus protein genetic variability in four Amerindian populations
The answer to the first question posed above is affirmative. However, the problem of whether the Aché derived from a Gê group that preceded the Guarani colonization of Paraguay, or are just a differentiated Guarani group, could not be answered with the genetic information available; the second hypothesis seems more likely at present, but the point to be emphasized is the striking genetic distinctiveness of the Aché as compared to other Amerindian…
Perfil de auto-anticorpos em índios das tribos Kaingang e Guarani do Sul do Brasil
This study investigated the autoantibody profile of 241 blood samples from 176 Kaingang and 65 Guarani Indians from three populations living on the Rio das Cobras and Ivaí reservations, in the state of Paraná, in southern Brazil. The presence of antimitochondrial, anti-smooth muscle, antinuclear, anti-parietal cell, and anti-liver-kidney microsome antibodies was determined by indirect immunofluorescence. These results were compared with samples f…
Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil
This article reports on a large longitudinal study, begun in 1993, of the natural history of human papillomavirus (HPV) infection and cervical neoplasia in a population of low-income women in São Paulo, Brazil, a city with one of the highest risks worldwide for cervical cancer. Known as the Ludwig-McGill cohort study, the epidemiological investigation focuses on persistent infection with oncogenic HPV types as the precursor event leading to cervi…
Electrophoretic protein polymorphisms in Kaingang and Guarani Indians of Southern Brazil
A total of 337 Kaingang and Guarani Indians from two localities were studied in relation to 18 protein genetic loci. In one of the localities, members of these two groups live side by side but show little genetic similarity, emphasizing the influence of cultural factors in the mating behavior of human groups. Integrating the present results with previous ones, it was verified that the genetic relationships among six Kaingang populations do not fo…
Electrophoretic protein polymorphisms in Kaingang and Guarani Indians of Southern Brazil
A total of 337 Kaingang and Guarani Indians from two localities were studied in relation to 18 protein genetic loci. In one of the localities, members of these two groups live side by side but show little genetic similarity, emphasizing the influence of cultural factors in the mating behavior of human groups. Integrating the present results with previous ones, it was verified that the genetic relationships among six Kaingang populations do not fo…
Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil
A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS-I), and a fraction of them was also studied for seven biallelic Y-chromosome polymorphisms. Nineteen HVS-I lineages were detected, which showed distinct distributions in the two tribes. The G ST value obtained with the mtDNA data is about 5 times highe…
The β‐globin gene cluster distribution revisited—Patterns in Native American populations
New frequencies for the β‐globin gene cluster haplotypes are presented for the Aché ( N = 82 individuals), Guarani ( N = 76), and Kaingang ( N = 54), three Native South American populations that live in an area between parallels 20°S and 30°S not covered by previous studies at this locus. The haplotype frequencies obtained for the three populations are within the interval observed for 28 other Native American populations. The Aché show much less …
Stability or variation? Patterns of lactase gene and its enhancer region distributions in Brazilian Amerindians
Lactase persistence (LP) is the phenotypic trait in which lactase secretion is maintained during adulthood. LP is due to mutations in the LCT enhancer region, located 14‐kb upstream of the gene. In Europeans, the −13910*T allele is associated with LP. In Africans this allele is rare while other mutations in this same region were related to LP. The LCT is highly polymorphic in human populations, but so far Brazilian Amerindians had not been invest…
Dopamine receptor D4 allele distribution in Amerindians: A reflection of past behavior differences
The DRD4 variable number of tandem repeats (VNTR) allele distribution of 172 Guarani (Kaiowá and Ñandeva subgroups) and Kaingang Brazilian Amerindians is reported. These results are integrated with those previously obtained for this ethnic group. Allele frequencies for the three populations are within the interval observed for 15 other Native American populations and show intermediate values between those observed in Amazonia and Patagonia. Signi…
Linkage disequilibrium patterns and genetic structure of Amerindian and non‐Amerindian Brazilian populations revealed by long‐range X‐STR markers
The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the …
Demographic and Genetic Structures of Two Partially Isolated Communities of Santa Catarina Island, Southern Brazil
The objectives of this study were to analyze the population structure and genetic variability of two communities, Costa da Lagoa (CLG) and São João do Rio Vermelho (SJRV), located on Santa Catarina Island in southern Brazil. The two populations descend from Azores Archipelago immigrants (Portuguese), with a minor contribution of sub-Saharan Africans and Amerindians. To estimate the relative contribution of the different ethnic groups to the curre…
Human T-cell lymphotropic virus type II in Guaraní Indians, Southern Brazil
Human T-cell lymphotropic virus type II (HTLV-II) is found in many New World Indian groups on the American continent. In Brazil, HTLV-II has been found among urban residents and Indians in the Amazon region, in the North. Guaraní Indians in the South of Brazil were studied for HTLV-I/II infection. Among 52 individuals, three (5.76%) showed positive anti-HTLV-II antibodies (enzyme-linked immunosorbent assay and Western blot). This preliminary repo…
Electrophoretic protein polymorphisms in Kaingang and Guarani Indians of Southern Brazil
A total of 337 Kaingang and Guarani Indians from two localities were studied in relation to 18 protein genetic loci. In one of the localities, members of these two groups live side by side but show little genetic similarity, emphasizing the influence of cultural factors in the mating behavior of human groups. Integrating the present results with previous ones, it was verified that the genetic relationships among six Kaingang populations do not fo…
Electrophoretic protein polymorphisms in Kaingang and Guarani Indians of Southern Brazil
A total of 337 Kaingang and Guarani Indians from two localities were studied in relation to 18 protein genetic loci. In one of the localities, members of these two groups live side by side but show little genetic similarity, emphasizing the influence of cultural factors in the mating behavior of human groups. Integrating the present results with previous ones, it was verified that the genetic relationships among six Kaingang populations do not fo…
Design and methods of the Ludwig-McGill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in Brazil
This article reports on a large longitudinal study, begun in 1993, of the natural history of human papillomavirus (HPV) infection and cervical neoplasia in a population of low-income women in São Paulo, Brazil, a city with one of the highest risks worldwide for cervical cancer. Known as the Ludwig-McGill cohort study, the epidemiological investigation focuses on persistent infection with oncogenic HPV types as the precursor event leading to cervi…
Perfil de auto-anticorpos em índios das tribos Kaingang e Guarani do Sul do Brasil
This study investigated the autoantibody profile of 241 blood samples from 176 Kaingang and 65 Guarani Indians from three populations living on the Rio das Cobras and Ivaí reservations, in the state of Paraná, in southern Brazil. The presence of antimitochondrial, anti-smooth muscle, antinuclear, anti-parietal cell, and anti-liver-kidney microsome antibodies was determined by indirect immunofluorescence. These results were compared with samples f…
Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians
Polymorphisms at the TP53 , cytochrome P‐450 ( CYP ), and glutathione S‐transferase ( GST ) genes are related to cancer susceptibility and present high diversity in allele frequencies among ethnic groups. This study concerns the CYP2E1 , GSTM1 , and GSTT1 polymorphisms in seven Amerindian populations (Xavante, Guarani, Aché, Wai Wai, Zoró, Surui, and Gavião). Polymorphic sites at CYP1A1 and TP53 were also studied in the Aché and Guarani tribes an…
Alu insertions versus blood group plus protein genetic variability in four Amerindian populations
The answer to the first question posed above is affirmative. However, the problem of whether the Aché derived from a Gê group that preceded the Guarani colonization of Paraguay, or are just a differentiated Guarani group, could not be answered with the genetic information available; the second hypothesis seems more likely at present, but the point to be emphasized is the striking genetic distinctiveness of the Aché as compared to other Amerindian…
Y-Chromosome Evidence for Differing Ancient Demographic Histories in the Americas
Demographic and Genetic Structures of Two Partially Isolated Communities of Santa Catarina Island, Southern Brazil
The objectives of this study were to analyze the population structure and genetic variability of two communities, Costa da Lagoa (CLG) and São João do Rio Vermelho (SJRV), located on Santa Catarina Island in southern Brazil. The two populations descend from Azores Archipelago immigrants (Portuguese), with a minor contribution of sub-Saharan Africans and Amerindians. To estimate the relative contribution of the different ethnic groups to the curre…
Geography influences microsatellite polymorphism diversity in Amerindians
Data related to 15 short tandem repeat polymorphisms (STRPs) are reported for four South American Indian populations, and integrated with previous Brazilian Indian results. Overall heterozygosities varied significantly among groups (Kruskal-Wallis test, P = 0.002). The lowest levels of heterozygosity were observed in the Ache, Ayoreo, and Surui, an expected finding considering their isolation and ethnohistory. Genetic distance and gene diversity …
Human T-cell lymphotropic virus type II in Guaraní Indians, Southern Brazil
Human T-cell lymphotropic virus type II (HTLV-II) is found in many New World Indian groups on the American continent. In Brazil, HTLV-II has been found among urban residents and Indians in the Amazon region, in the North. Guaraní Indians in the South of Brazil were studied for HTLV-I/II infection. Among 52 individuals, three (5.76%) showed positive anti-HTLV-II antibodies (enzyme-linked immunosorbent assay and Western blot). This preliminary repo…
Demographic and evolutionary trajectories of the Guarani and Kaingang natives of Brazil
A total of 278 individuals from two Brazilian Indian tribes (Guarani and Kaingang) living in five different localities had their mitochondrial DNA sequenced for the first hypervariable segment (HVS-I), and a fraction of them was also studied for seven biallelic Y-chromosome polymorphisms. Nineteen HVS-I lineages were detected, which showed distinct distributions in the two tribes. The G ST value obtained with the mtDNA data is about 5 times highe…
Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower gen…
The β‐globin gene cluster distribution revisited—Patterns in Native American populations
New frequencies for the β‐globin gene cluster haplotypes are presented for the Aché ( N = 82 individuals), Guarani ( N = 76), and Kaingang ( N = 54), three Native South American populations that live in an area between parallels 20°S and 30°S not covered by previous studies at this locus. The haplotype frequencies obtained for the three populations are within the interval observed for 28 other Native American populations. The Aché show much less …
Cystic Fibrosis Gene Variability in Two Southern Brazilian Amerindian Populations: Analysis of the ΔF508 Mutation and the KM19 and XV2C Haplotypes
The frequencies of the deltaF508 deletion, the most common cystic fibrosis mutation in Europeans and European-derived populations, and the XV2C and KM19 restriction fragment length polymorphisms that are tightly linked to the CFTR locus vary among populations. To determine the distribution of these extragenic markers and of the deltaF508 mutation, we analyzed 326 chromosomes of individuals from two South American Indian populations, the Guarani a…
Geographic Patterns of Genome Admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for…
Mitochondrial Population Genomics Supports a Single Pre-Clovis Origin with a Coastal Route for the Peopling of the Americas
Y‐STR analysis in Brazilian and South Amerindian populations
A sample of 203 Brazilian males from Rio Grande do Sul (RS), the Brazilian southernmost state, was typed for 11 Y‐STR markers (DYS19, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, and DYS439). We also typed 42 individuals from two South Amerindian tribes (Kaingang and Guarani) to use the data as parental Amerindian contribution to our analyses. Gene and haplotypic diversities were estimated, with the South Amerindian samples…
Linkage disequilibrium patterns and genetic structure of Amerindian and non‐Amerindian Brazilian populations revealed by long‐range X‐STR markers
The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the …
Dopamine receptor D4 allele distribution in Amerindians: A reflection of past behavior differences
The DRD4 variable number of tandem repeats (VNTR) allele distribution of 172 Guarani (Kaiowá and Ñandeva subgroups) and Kaingang Brazilian Amerindians is reported. These results are integrated with those previously obtained for this ethnic group. Allele frequencies for the three populations are within the interval observed for 15 other Native American populations and show intermediate values between those observed in Amazonia and Patagonia. Signi…
Variability of the BCHE gene in Amerindians from Paraná, Brazil
Despite the geographical coexistence throughout their dispersion, each of these two Amerindian groups retains a high degree of genetic identity, probably maintained by cultural and social isolation
Reconstructing Native American population history
Stability or variation? Patterns of lactase gene and its enhancer region distributions in Brazilian Amerindians
Lactase persistence (LP) is the phenotypic trait in which lactase secretion is maintained during adulthood. LP is due to mutations in the LCT enhancer region, located 14‐kb upstream of the gene. In Europeans, the −13910*T allele is associated with LP. In Africans this allele is rare while other mutations in this same region were related to LP. The LCT is highly polymorphic in human populations, but so far Brazilian Amerindians had not been invest…
Genetic evidence for two founding populations of the Americas
Variability of innate immune system genes in Native A merican populations—relationship with history and epidemiology
OBJECTIVES: The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. MATERIALS AND METHODS: We investigated heterozygozities and patterns …
Biology (21 works) · Gene (17 works) · Demography (16 works) · Population (16 works) · Evolutionary biology (15 works) · Genetics (15 works) · Geography (14 works) · Forensic and Genetic Research (13 works) · Allele (12 works) · Genetics (12 works)