Linkage disequilibrium patterns and genetic structure of Amerindian and non‐Amerindian Brazilian populations revealed by long‐range X‐STR markers

Bibliographic Data

ID8320459
AuthorsFabio P N Leite (Universidade Federal do Rio Grande do Sul), Sidney Emanuel Batista Dos Santos (0000-0002-8622-9417, Universidade Federal do Pará), Elzemar M R Rodríguez (Universidade Federal do Pará), Sidia M Callegari‐jacque (0000-0002-2489-2539, Universidade Federal do Rio Grande do Sul), Sidia M Callegari‐Jacques, Darío Alfredo Demarchi (0000-0003-3782-8269, Universidad Nacional de Córdoba), Luiza Tamie Tsuneto (Universidade Federal do Paraná), M Luiza Petzl‐erler (0000-0002-0345-5276, Universidade Federal do Paraná), Francisco M Salzano (0000-0002-4753-3184, Universidade Federal do Rio Grande do Sul), Mara H Hutz (0000-0002-9146-1229, Universidade Federal do Rio Grande do Sul, corresponding author)
Year2009
Volume139
Issue3
Pages404-412
Publication date2009-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Physical Anthropology (JOURNAL)
Journal identifiersISSN: 0002-9483 • E-ISSN: 1096-8644
PublisherWiley (PUBLISHER • GB)
DOI10.1002/ajpa.20998
PMID19170209
OpenAlexW2115608922
LanguageEN
Citations received3
References cited48

The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the Amerindian pool. On the other hand, the LD levels of the non‐Amerindian Brazilian sample, although less extensive than that of the Amerindians, were probably determined by admixture events. Our results indicated that different demographic histories have significant effects on LD levels of human populations, and provide a first approach to the X‐chromosome ancestry of Amerindian and non‐Amerindian Brazilian populations, being valuable for future studies involving mapping and population genetic studies. Am J Phys Anthropol 2009. © 2009 Wiley‐Liss, Inc

Allele · Biology · Evolutionary biology · Gene · Genetic diversity · Genetic structure · Genetic variation · Genotype · Haplotype · Linkage (software) · Linkage Disequilibrium · Microsatellite · Population · Range (aeronautics) · Y chromosome · Demography · Forensic and Genetic Research · Genetic Associations and Epidemiology · Genetic diversity and population structure · Genetics

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