The cost of dichotomising continuous variables
Dados Bibliográficos
| ID | 23344132 |
|---|---|
| Autores | David G Altman (0000-0002-7183-4083, Cancer Research UK), Douglas G Altman, Patrick Royston (MRC Clinical Trials Unit at UCL) |
| Ano | 2006 |
| Volume | 332 |
| Fascículo | 7549 |
| Páginas | 1080.1 |
| Data de publicação | 2006-05-06 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | BMJ (JOURNAL) |
| Identificadores do periódico | ISSN: 0007-1447 • E-ISSN: 0267-0623 |
| Editora | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/bmj.332.7549.1080 |
| PMID | 16675816 |
| PMCID | PMC1458573 |
| OpenAlex | W1969298821 |
| Idioma | EN |
| Citações recebidas | 183 |
| Referências citadas | 3 |
Myeloid-derived suppressor cells (MDSCs) are present in elevated numbers in TB patients and have been found to be permissive for Mycobacterium tuberculosis ( Mtb ) proliferation. To determine whether depletion of MDSCs may improve host control of TB, we used a novel diphtheria toxin-based fusion protein known as DABIL-4 that targets and depletes IL-4-receptor positive cells. We show that DABIL-4 depletes both PMN-MDSCs and M-MDSC in the mouse TB model, and that it reduces the lung bacillary burden of Mtb . These results indicate that MDSC-depleting therapies targeting the IL4 receptor are beneficial in TB and offer an avenue towards host-directed TB therapy.
Data science · Information retrieval · World Wide Web · Computer Science · Immune cells in cancer · Immune Response and Inflammation · TGF-β signaling in diseases
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Associations of positive childhood experiences with disordered eating attitudes and behaviors among Korean college students
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Factor structure and measurement invariance of the older people’s quality of life scale
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A moderated mediation model linking financial difficulties to support for violent radicalization
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Type D personality is associated with lower cardiovascular reactivity to stress in women
Teacher burnout and physical health
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Ten years of augmented reality in education
Social problems in young children
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What makes a lonely child
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| Obras citantes distintas | 183 |
|---|---|
| Citações por ano | 10,76 |
| Intervalo de citações | 2009 - 2026 (18) |
| Velocidade de citação | current |
| Altamente citado | Sim |
| Tipos de citação | Neutras: 176 |