Gender and Race/Ethnicity Differences in Lead Dose Biomarkers

Bibliographic Data

ID11017442
AuthorsKeson Theppeang (Keson Theppeang and Brian S. Schwartz are with the Department of Environmental Health Sciences, Division of Occupational and Environmental Health; Thomas A. Glass and Brian S. Schwartz are with the Department of Epidemiology; and Keson Theppeang, Karen Bandeen-Roche, and Charles A. Rohde are with the Department of Biostatistics, all at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Andrew C. Todd is with the Department of Community and Preventive Medicine, Mount Sinai School of...), Thomas A Gla (0000-0003-4399-612X, Johns Hopkins University), Thomas A Glass (Keson Theppeang and Brian S. Schwartz are with the Department of Environmental Health Sciences, Division of Occupational and Environmental Health; Thomas A. Glass and Brian S. Schwartz are with the Department of Epidemiology; and Keson Theppeang, Karen Bandeen-Roche, and Charles A. Rohde are with the Department of Biostatistics, all at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Andrew C. Todd is with the Department of Community and Preventive Medicine, Mount Sinai School of...), Karen Bandeen-Roche (0000-0003-3895-8313, Keson Theppeang and Brian S. Schwartz are with the Department of Environmental Health Sciences, Division of Occupational and Environmental Health; Thomas A. Glass and Brian S. Schwartz are with the Department of Epidemiology; and Keson Theppeang, Karen Bandeen-Roche, and Charles A. Rohde are with the Department of Biostatistics, all at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Andrew C. Todd is with the Department of Community and Preventive Medicine, Mount Sinai School of...), Andrew C Todd (0000-0001-7864-009X, Keson Theppeang and Brian S. Schwartz are with the Department of Environmental Health Sciences, Division of Occupational and Environmental Health; Thomas A. Glass and Brian S. Schwartz are with the Department of Epidemiology; and Keson Theppeang, Karen Bandeen-Roche, and Charles A. Rohde are with the Department of Biostatistics, all at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Andrew C. Todd is with the Department of Community and Preventive Medicine, Mount Sinai School of...), Charles A Rohde (0000-0002-7671-2480, Keson Theppeang and Brian S. Schwartz are with the Department of Environmental Health Sciences, Division of Occupational and Environmental Health; Thomas A. Glass and Brian S. Schwartz are with the Department of Epidemiology; and Keson Theppeang, Karen Bandeen-Roche, and Charles A. Rohde are with the Department of Biostatistics, all at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Andrew C. Todd is with the Department of Community and Preventive Medicine, Mount Sinai School of...), Brian S Schwartz (0000-0002-0739-9865, Keson Theppeang and Brian S. Schwartz are with the Department of Environmental Health Sciences, Division of Occupational and Environmental Health; Thomas A. Glass and Brian S. Schwartz are with the Department of Epidemiology; and Keson Theppeang, Karen Bandeen-Roche, and Charles A. Rohde are with the Department of Biostatistics, all at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Andrew C. Todd is with the Department of Community and Preventive Medicine, Mount Sinai School of...)
Year2008
Volume98
Issue7
Pages1248-1255
Publication date2008-07-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2007.118505
PMID18511728
PMCIDPMC2424096
OpenAlexW2123278150
LanguageEN
Citations received6
References cited62

Objectives. We sought to identify predictors of lead concentrations in the blood, tibias, and patellae of older adults and to describe differences by gender, race/ethnicity, and other factors that can influence lead toxicokinetics and, thus modify health effects. Methods. Participants aged 50 to 70 years (N=1140) were randomly identified from selected neighborhoods in Baltimore, Maryland. We measured lead concentrations by anodic stripping voltammetry (in blood) and 109 Cd-induced K-shell x-ray fluorescence (in bone). We used multiple linear regression to identify predictors of lead concentrations. Results. Mean (SD) lead concentrations in blood, tibias, and patellae were 3.5 (2.4) μg/dL, 18.9 (12.5) μg/g, and 6.8 (18.1) μg/g, respectively. Tibia concentrations were 29% higher in African Americans than in Whites (P Conclusions. African Americans evidenced a prominent disparity in lifetime lead dose. Women may be at higher risk of release of lead from bone and consequent health effects because of increased bone demineralization with aging

Biology · Confounding · Ethnic group · Lead (geology) · Lead exposure · Demography · Heavy Metal Exposure and Toxicity · Heavy metals in environment · Internal Medicine · Medicine · Mercury impact and mitigation studies · Physiology

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