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Principles for Designing Randomized Preventive Trials in Mental Health

An Emerging Developmental Epidemiology Paradigm

Bibliographic Data

ID11054342
AuthorsC H Brown (0000-0002-0294-2419, Department of Epidemiology and Bioslatistics University of South Florida U. S. A.), Jason Liao (Department of Epidemiology and Bioslatistics University of South Florida U. S. A.), Jiangang Liao (0000-0001-7649-1553, University of South Florida)
Year1999
Volume27
Issue5
Pages673-710
Publication date1999-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAmerican Journal of Community Psychology (JOURNAL)
Journal identifiersISSN: 0091-0562 • E-ISSN: 1573-2770
PublisherWiley (PUBLISHER • GB)
DOI10.1023/a:1022142021441
PMID10676544
OpenAlexW1774286576
LanguageEN
Citations received23
References cited70

An emerging population‐based paradigm is now being used to guide the design of preventive trials used to test developmental models. We discuss elements of the designs of several ongoing randomized preventive trials involving reduction of risk for children of divorce, for children who exhibit behavioral or learning problems, and for children whose parents are being treated for depression. To test developmental models using this paradigm, we introduce three classes of design issues: design for prerandomization, design for intervention, and design for postintervention. For each of these areas, we present quantitative results from power calculations. Both scientific and cost implications of these power calculations are discussed in terms of variation among subjects on preintervention measures, unit of intervention, assignment, balancing, number of pretest and posttest measures, and the examination of moderation effects

Clinical study design · Clinical trial · Environmental health · Health psychology · Intervention (counseling) · Mental health · Moderation · Population · Psychiatry · Public health · Randomized controlled trial · Research design · Test (biology) · Applied Psychology · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Early Childhood Education and Development · Maternal Mental Health During Pregnancy and Postpartum · Medicine · Nursing · Psychology · Social Psychology

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Unique citing works23
Citations per year0,85
Citation span1999 - 2021 (23)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 22

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