Effects of serotonin-mimetic drugs on mouse-killing behavior

Bibliographic Data

ID11107128
AuthorsVictor A Molina, Vı́ctor A Molina (Centre National de la Recherche Scientifique), Serge Gobaille (Centre National de la Recherche Scientifique), Paul Mandel (Centre National de la Recherche Scientifique)
Year1986
Volume12
Issue3
Pages201-211
Publication date1986-01-01
Open AccessYes
TypeARTICLE
VenueAggressive Behavior (JOURNAL)
Journal identifiersISSN: 0096-140X • E-ISSN: 1098-2337
PublisherWiley (PUBLISHER • GB)
DOI10.1002/1098-2337(1986)12:3<201::aid-ab2480120307>3.0.co;2-5
OpenAlexW2023418528
LanguageEN
Citations received2
References cited25

Muricidal behavior induced in rats by social isolation or by olfactory bulb ablation was blocked following IP administration of serotonin (5–HT) agonist 8-OH-DPAT and 5-MeODM and by 5-HT uptake inhibitors, fluoxetine and indalpine. Among uptake inhibitors, although fluoxetine has a higher IC50 and a higher Ki, it is apparently more efficient than indalpine. The 5-HT agonist, 8-OH-DPAT, acting at a putative 5-HT1A receptor, appears more efficient on muricidal inhibition than 5-MeODM, at a much lower dosage. It is highly probable that 5-HT1A receptor rather than 5-HT1B is involved in the antimuricidal effect of serotonin-mimetic drugs. Since 5-HT mimetic drugs blocked mouse-killing behavior of bulbectomized rats, we suggest that in the sequence of events in muricidal inhibition 5-HT circuits participate after gabaergic modulation from olfactory bulbs.

5-HT receptor · Agonist · Antidepressant · Biology · Central nervous system · Fluoxetine · Hippocampus · Olfactory bulb · Receptor · Serotonin · Serotonin Agonist · Chemistry · Endocrinology · Internal Medicine · Medicine · Neurotransmitter Receptor Influence on Behavior · Nicotinic Acetylcholine Receptors Study · Olfactory and Sensory Function Studies · Pharmacology

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