Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man

Bibliographic Data

ID11106537
AuthorsElla M Nikulina (0000-0003-0788-4665, Institute of Cytology and Genetics, corresponding author), Damira F Avgustinovich, Д Ф Августинович (0000-0003-2462-3520, Institute of Cytology and Genetics), Nina K Popova, Н К Попова (Institute of Cytology and Genetics)
Year1992
Volume18
Issue5
Pages357-364
Publication date1992-01-01
Open AccessYes
TypeARTICLE
VenueAggressive Behavior (JOURNAL)
Journal identifiersISSN: 0096-140X • E-ISSN: 1098-2337
PublisherWiley (PUBLISHER • GB)
DOI10.1002/1098-2337(1992)18:5<357::aid-ab2480180505>3.0.co;2-c
OpenAlexW2038725401
LanguageEN
Citations received2
References cited20

The 5HT1A receptor agonist ipsapirone (10 mg/kg) suppressed shock-induced aggression in wild and domesticated rats but did not affect predatory aggression in either group of animals. Ipsapirone decreased neophobia and inhibited defensive reactions by wild rats towards man in the glove test. [3H]8-OH-DPAT binding, which labels 5HT1A receptors, was significantly increased in the hypothalamus of domesticated rats in comparison with wild counterparts, while 5HT1A density was unchanged in the frontal cortex in domesticated animals. In essence, the aggressive reactions contributing to the defensive behavior complex in wild rats appear to be regulated through 5HT1A receptors. © 1992 Wiley-Liss, Inc.

5-HT receptor · Aggression · Agonist · Biology · Developmental psychology · Domestication · Hypothalamus · Ipsapirone · Neophobia · Receptor · Serotonin · Chemistry · Ecology · Endocrinology · Internal Medicine · Medicine · Neuroendocrine regulation and behavior · Psychology · Receptor Mechanisms and Signaling · Stress Responses and Cortisol

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