Selection for reduced aggressiveness towards man and dopaminergic activity in Norway rats
Bibliographic Data
| ID | 11105385 |
|---|---|
| Authors | Ella M Nikulina (0000-0003-0788-4665, Institute of Cytology and Genetics, corresponding author), Damira F Avgustinovich, Д Ф Августинович (0000-0003-2462-3520, Institute of Cytology and Genetics), Nina K Popova, Н К Попова (Institute of Cytology and Genetics) |
| Year | 1992 |
| Volume | 18 |
| Issue | 1 |
| Pages | 65-72 |
| Publication date | 1992-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Aggressive Behavior (JOURNAL) |
| Journal identifiers | ISSN: 0096-140X • E-ISSN: 1098-2337 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/1098-2337(1992)18:1<65::aid-ab2480180108>3.0.co;2-y |
| OpenAlex | W2089062908 |
| Language | EN |
| Citations received | 3 |
| References cited | 17 |
The brain dopaminergic system is involved in the process of long-term selection for reduced aggressive reaction towards man in Norway rats. The dopamine levels in the striatum as well as the nucleus accumbens with the tuberculum olfactorium were significantly lower in domesticated rats than in their wild counterparts. A substantial decrease was found in homovanillic acid level in the n. accumbens and tuberculum olfactorium. Specific binding of [3H]spiperone which labels D-2 dopamine receptors was higher in the mesolimbic structure of tame rats, whereas binding of [3H]SCH 23390 (D-1 receptors) was unchanged in this area. No substantial differences were detected in D-1 and D-2 binding in striatum. Apomorphine (0.3 mg/kg) elicited less locomotion in tame animals, reflecting a decrease of sensitivity of postsynaptic dopamine receptors. Tame rats showed fewer aggressive contacts in a foot-shock test than wild rats and the D-2 receptor antagonist sulpiride (25 mg/kg) significantly decreased the foot-shock aggression only in wild rats. Therefore, domestication, which diminishes defensive behavior and emotional reactivity of animals, is associated with decreases of dopamine level in the striatum, changed metabolism of dopamine in mesolimbic system, and an alteration in density and senstivity of D-2 receptors.
Apomorphine · Biology · Dopamine · Dopamine receptor · Dopaminergic · Nucleus accumbens · Receptor · SCH-23390 · Striatum · Sulpiride · Chemistry · Endocrinology · Internal Medicine · Meat and Animal Product Quality · Medicine · Neuroendocrine regulation and behavior · Neuroscience · Neurotransmitter Receptor Influence on Behavior
Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man
Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A
Defensive reactions of “wild-type” and “Domesticated” wild rats to approach and contact by a threat stimulus
| Citations per year | 0.09 |
|---|---|
| Citation span | 1992 - 1994 (3) |
| Highly cited | No |