Н К Попова
Biographic Data
| ID | 10576929 |
|---|---|
| NAME | Н К Попова |
| GIVEN NAMES | Н К |
| FAMILY NAME | Попова |
| SIGNATURE | ПОПОВА Н К |
| AFFILIATIONS | Institute of Cytology and Genetics |
| VERIFIED | No |
| TOTAL WORKS | 9 |
| TOTAL CITATIONS | 1 |
| WORKS AS AUTHOR | 9 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1986 |
| LATEST PUBLICATION YEAR | 2007 |
| H-INDEX | 1 |
Effect of MAO A deficiency on different kinds of aggression and social investigation in mice
Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression. Different kinds of aggression were investigated in Tg8, a transgenic mouse strain lacking a functional MAO A gene. MAO A‐deficient mice differ from wild‐type C3H/HeJ (C3H) in terms of showing higher territorial, predatory and isolation‐induced aggression. Tg8 demonstrated shorter latencies to cricket killing and…
Association between intermale aggression and genetically-defined tryptophan hydroxylase activity in the mouse brain
The relationship between the genetically defined intensity of intermale aggression and the activity of brain tryptophan hydroxylase (TPH) has been studied in inbred mice. No association between the enzyme activity and the percentage of aggressive mice (reflecting the predisposition to aggressive reaction) was revealed. However, a significant positive interstrain correlation between brain TPH activity and accumulated attacking time (reflecting fig…
Defensive reactions of “wild-type” and “Domesticated” wild rats to approach and contact by a threat stimulus
Selective breeding of wild rats over many generations on the basis of low or high defensive threat and attack to human approach and contact has produced highly polarized “domesticated” and “wild-type” animals. Because the selection procedure selectively involves these two defense patterns, and these clearly differ in the two groups, it is of interest to determine if other, nonselected, defensive behaviors to threat stimuli also change. “Domestica…
Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man
The 5HT1A receptor agonist ipsapirone (10 mg/kg) suppressed shock-induced aggression in wild and domesticated rats but did not affect predatory aggression in either group of animals. Ipsapirone decreased neophobia and inhibited defensive reactions by wild rats towards man in the glove test. [3H]8-OH-DPAT binding, which labels 5HT1A receptors, was significantly increased in the hypothalamus of domesticated rats in comparison with wild counterparts…
Selection for reduced aggressiveness towards man and dopaminergic activity in Norway rats
The brain dopaminergic system is involved in the process of long-term selection for reduced aggressive reaction towards man in Norway rats. The dopamine levels in the striatum as well as the nucleus accumbens with the tuberculum olfactorium were significantly lower in domesticated rats than in their wild counterparts. A substantial decrease was found in homovanillic acid level in the n. accumbens and tuberculum olfactorium. Specific binding of [3…
Serotonin metabolism and serotonergic receptors in Norway rats selected for low aggressiveness to man
Selection of Norway rats (24–27 generations) for low aggressiveness to man resulting in the loss of aggressive responding to handling markedly influences the brain serotonergic system. In “domesticated” Norway rats levels of serotonin in the midbrain and hypothalamus and 5-hydroxyindole acetic acid in the hypothalamus were higher than in non-selected aggressive rats. The activity of the key enzyme in serotonin biosynthesis, tryptophan hydroxylase…
Predatory aggression in the mink (Mustela vison)
5-Hydroxytrypotophan at a dose of 50 mg/kg intraperitoneally (i.p.) sharply increased neural serotonin (5-HT) levels in mink and considerably inhibited that animal's predatory attack on rats. Intraperitoneal injection of 5-HT (10 and 20 mg/kg) did not influence such rat-killing. Neural levels of 5-HT or 5-hydroxyindoleacetic acid (5-HIAA) and subsequent aggression by the predator did not change to any great degree after ingestion of a single meal…
Serotonin's influence on predatory behavior of highly aggressive cba and weakly aggressive DD strains of mice
The effects of serotonin were studied on locust-killing behavior of mice from low (DD) and high (CBA) predatory aggressive strains. 5-HTP injected intraperitoneally (50 and 100 mg/kg) or 5-HT administered into the lateral ventricle (10 μg) significantly reduced locust-killing behavior in highly aggressive CBA mice. Imipramine (20, 30, and 40 mg/kg) elicited a dose-dependent inhibitory effect on predatory behavior. Fluoxetine (10 and 20 mg/kg) alo…
Genetic analysis of “Spontaneous” intermale aggression in mice
“Spontaneous” intermale aggression was investigated in seven inbred strains of mice. A positive interstrain correlation and cross-correlation was found for two indices of fighting intensity, ie, accumulated attacking time and number of attacks. The strain aggressiveness level (percent of mice fighting in each strain) does not correlate with the intensity of aggressive behavior. It has been shown by using a genetical analysis performed on C57BL/6 …
Effect of MAO A deficiency on different kinds of aggression and social investigation in mice
Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression. Different kinds of aggression were investigated in Tg8, a transgenic mouse strain lacking a functional MAO A gene. MAO A‐deficient mice differ from wild‐type C3H/HeJ (C3H) in terms of showing higher territorial, predatory and isolation‐induced aggression. Tg8 demonstrated shorter latencies to cricket killing and…
Serotonin's influence on predatory behavior of highly aggressive cba and weakly aggressive DD strains of mice
The effects of serotonin were studied on locust-killing behavior of mice from low (DD) and high (CBA) predatory aggressive strains. 5-HTP injected intraperitoneally (50 and 100 mg/kg) or 5-HT administered into the lateral ventricle (10 μg) significantly reduced locust-killing behavior in highly aggressive CBA mice. Imipramine (20, 30, and 40 mg/kg) elicited a dose-dependent inhibitory effect on predatory behavior. Fluoxetine (10 and 20 mg/kg) alo…
Genetic analysis of “Spontaneous” intermale aggression in mice
“Spontaneous” intermale aggression was investigated in seven inbred strains of mice. A positive interstrain correlation and cross-correlation was found for two indices of fighting intensity, ie, accumulated attacking time and number of attacks. The strain aggressiveness level (percent of mice fighting in each strain) does not correlate with the intensity of aggressive behavior. It has been shown by using a genetical analysis performed on C57BL/6 …
Predatory aggression in the mink (Mustela vison)
5-Hydroxytrypotophan at a dose of 50 mg/kg intraperitoneally (i.p.) sharply increased neural serotonin (5-HT) levels in mink and considerably inhibited that animal's predatory attack on rats. Intraperitoneal injection of 5-HT (10 and 20 mg/kg) did not influence such rat-killing. Neural levels of 5-HT or 5-hydroxyindoleacetic acid (5-HIAA) and subsequent aggression by the predator did not change to any great degree after ingestion of a single meal…
Serotonin metabolism and serotonergic receptors in Norway rats selected for low aggressiveness to man
Selection of Norway rats (24–27 generations) for low aggressiveness to man resulting in the loss of aggressive responding to handling markedly influences the brain serotonergic system. In “domesticated” Norway rats levels of serotonin in the midbrain and hypothalamus and 5-hydroxyindole acetic acid in the hypothalamus were higher than in non-selected aggressive rats. The activity of the key enzyme in serotonin biosynthesis, tryptophan hydroxylase…
Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man
The 5HT1A receptor agonist ipsapirone (10 mg/kg) suppressed shock-induced aggression in wild and domesticated rats but did not affect predatory aggression in either group of animals. Ipsapirone decreased neophobia and inhibited defensive reactions by wild rats towards man in the glove test. [3H]8-OH-DPAT binding, which labels 5HT1A receptors, was significantly increased in the hypothalamus of domesticated rats in comparison with wild counterparts…
Selection for reduced aggressiveness towards man and dopaminergic activity in Norway rats
The brain dopaminergic system is involved in the process of long-term selection for reduced aggressive reaction towards man in Norway rats. The dopamine levels in the striatum as well as the nucleus accumbens with the tuberculum olfactorium were significantly lower in domesticated rats than in their wild counterparts. A substantial decrease was found in homovanillic acid level in the n. accumbens and tuberculum olfactorium. Specific binding of [3…
Defensive reactions of “wild-type” and “Domesticated” wild rats to approach and contact by a threat stimulus
Selective breeding of wild rats over many generations on the basis of low or high defensive threat and attack to human approach and contact has produced highly polarized “domesticated” and “wild-type” animals. Because the selection procedure selectively involves these two defense patterns, and these clearly differ in the two groups, it is of interest to determine if other, nonselected, defensive behaviors to threat stimuli also change. “Domestica…
Association between intermale aggression and genetically-defined tryptophan hydroxylase activity in the mouse brain
The relationship between the genetically defined intensity of intermale aggression and the activity of brain tryptophan hydroxylase (TPH) has been studied in inbred mice. No association between the enzyme activity and the percentage of aggressive mice (reflecting the predisposition to aggressive reaction) was revealed. However, a significant positive interstrain correlation between brain TPH activity and accumulated attacking time (reflecting fig…
Effect of MAO A deficiency on different kinds of aggression and social investigation in mice
Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression. Different kinds of aggression were investigated in Tg8, a transgenic mouse strain lacking a functional MAO A gene. MAO A‐deficient mice differ from wild‐type C3H/HeJ (C3H) in terms of showing higher territorial, predatory and isolation‐induced aggression. Tg8 demonstrated shorter latencies to cricket killing and…
Biology (9 works) · Medicine (8 works) · Endocrinology (7 works) · Internal Medicine (7 works) · Aggression (6 works) · Neurotransmitter Receptor Influence on Behavior (6 works) · Serotonin (6 works) · Developmental psychology (5 works) · Neuroendocrine regulation and behavior (5 works) · Psychology (5 works)