Serotonin metabolism and serotonergic receptors in Norway rats selected for low aggressiveness to man
Bibliographic Data
| ID | 11105509 |
|---|---|
| Authors | Nina K Popova, Н К Попова (Institute of Cytology and Genetics, corresponding author), Alexander V Kulikov, А В Куликов (0000-0003-3816-6244, Institute of Cytology and Genetics), Ella M Nikulina (0000-0003-0788-4665, Institute of Cytology and Genetics), Eugenia Y Kozlachkova, Galina B Maslova |
| Year | 1991 |
| Volume | 17 |
| Issue | 4 |
| Pages | 207-213 |
| Publication date | 1991-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Aggressive Behavior (JOURNAL) |
| Journal identifiers | ISSN: 0096-140X • E-ISSN: 1098-2337 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1002/1098-2337(1991)17:4<207::aid-ab2480170403>3.0.co;2-2 |
| OpenAlex | W2037269998 |
| Language | EN |
| Citations received | 10 |
| References cited | 8 |
Selection of Norway rats (24–27 generations) for low aggressiveness to man resulting in the loss of aggressive responding to handling markedly influences the brain serotonergic system. In “domesticated” Norway rats levels of serotonin in the midbrain and hypothalamus and 5-hydroxyindole acetic acid in the hypothalamus were higher than in non-selected aggressive rats. The activity of the key enzyme in serotonin biosynthesis, tryptophan hydroxylase, in midbrain of rats with genetically determined lack of aggressiveness to man was higher than in aggressive animals, although there was no difference in tryptophan hydroxylase activity in the hypothalamus. Bmax and KD of [3H]spiperone-specific binding in frontal cortex membranes were increased in tame rats. No significant differences in Bmax and KD were found between “domesticated” and aggressive rats in [3H]serotonin binding in the frontal cortex.
5-HT receptor · 5-Hydroxyindoleacetic acid · Amino acid · Biology · Central nervous system · Cortex (anatomy) · Hypothalamus · Midbrain · Receptor · Serotonergic · Serotonin · Tryptophan · Tryptophan hydroxylase · Biochemistry · Chemistry · Endocrinology · Internal Medicine · Medicine · Neuroendocrine regulation and behavior · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Receptor Mechanisms and Signaling
Effect of MAO A deficiency on different kinds of aggression and social investigation in mice
Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man
Tyrosine hydroxylase activities in the brains of wild Norway rats and silver foxes selected for reduced aggressiveness towards humans
Stress and the Individual
Abnormal Behavior Associated with a Point Mutation in the Structural Gene for Monoamine Oxidase A
Pathways to Animal Domestication
The relationship between aggressive and sexual behavior in male mice
Defensive reactions of “wild-type” and “Domesticated” wild rats to approach and contact by a threat stimulus
Association between intermale aggression and genetically-defined tryptophan hydroxylase activity in the mouse brain
Selection for reduced aggressiveness towards man and dopaminergic activity in Norway rats
| Citations per year | 0.29 |
|---|---|
| Citation span | 1992 - 2012 (21) |
| Highly cited | No |