Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity
Bibliographic Data
| ID | 11179439 |
|---|---|
| Authors | Simon Gilbody (0000-0002-8236-6983), Tracy Lightfoot, Trevor Sheldon |
| Year | 2007 |
| Volume | 61 |
| Issue | 7 |
| Pages | 631-637 |
| Publication date | 2007-07-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.2006.050385 |
| PMID | 17568057 |
| PMCID | PMC2465760 |
| Language | EN |
| Citations received | 16 |
| References cited | 46 |
Low folate has been causatively linked to depression, but research is contradictory. An association may arise due to chance, bias, confounding or reverse causality. A systematic review of observational studies which examined the association between depression and folate was conducted. 11 relevant studies (15 315 participants; three case–control studies, seven population surveys and one cohort study) examining the risk of depression in the presence of low folate were found. Pooling showed a significant relationship between folate status and depression (odds ratio (OR) pooled unadjusted = 1.55; 95% CI 1.26 to 1.91). This relationship remained after adjustment for potential confounding (OR) pooled adjusted = 1.42; 95% CI 1.10 to 1.83). Folate levels were also lower in depression. There is accumulating evidence that low folate status is associated with depression. Much of this evidence comes from case–control and cross-sectional studies. Cohort studies and definitive randomised-controlled trials to test the therapeutic benefit of folate are required to confirm or refute a causal relationship
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| Unique citing works | 16 |
|---|---|
| Citations per year | 0.89 |
| Citation span | 2008 - 2023 (16) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 16 |