Effects of Reduced Central and Peripheral Catecholamines on Avoidance Learning
Bibliographic Data
| ID | 13670416 |
|---|---|
| Authors | John J Clancy (Mercy University), John Clancy (Mercy University, corresponding author), Donald F Caldwell (Lafayette Clinic), Charles E Frohman (Lafayette Clinic) |
| Year | 1981 |
| Volume | 49 |
| Issue | 1 |
| Pages | 35-44 |
| Publication date | 1981-08-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Psychological Reports (JOURNAL) |
| Journal identifiers | ISSN: 0033-2941 • E-ISSN: 1558-691X |
| Publisher | SAGE Publishing (PUBLISHER • US) |
| DOI | 10.2466/pr0.1981.49.1.35 |
| PMID | 7291429 |
| OpenAlex | W2042199310 |
| Language | EN |
| References cited | 19 |
Adult male Sprague-Dawley rats were randomly divided into 3 groups of 10. Using an independent-groups design the 6-hydroxydopamine animals received intraventricular and IP injections of the drug. The sham drug rats received intraventricular and IP injections of a vehicle solution while the control subjects were not injected. When administered either centrally or peripherally, 6-hydroxydopamine specifically and extensively depletes catecholamine levels. All rats were consequently given 30 trials per day over a 5-day period on a one-way active avoidance jump task. Using latency of response and number of avoidance responses as criteria, drug-induced depletion of central and peripheral catecholamines significantly retarded and in half the rats totally inhibited the acquisition of the one-way avoidance response. The results were discussed in relation to recent empirical findings on reduced catecholamine levels and avoidance behavior. Theoretically the results were interpreted as supporting Mowrer's two-factor learning theory and in conflict with DiGiusto and King's hypothesis about “difficulty of task.”
Anesthesia · Avoidance learning · Avoidance response · Catecholamine · Developmental psychology · Dopamine · Dopaminergic · Hydroxydopamine · Latency (audio · Peripheral · Task (project management · Behavioral and Psychological Studies · Internal Medicine · Medicine · Memory and Neural Mechanisms · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology
| Highly cited | No |
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