Methaemoglobin and erythrocyte reducing systems in high-altitude natives

Bibliographic Data

ID13921708
AuthorsJ Arnaud (Instituto Boliviano de Ciencia y Tecnología Nuclear, corresponding author), J C Quilici, Nancy Gutierrez (Instituto Boliviano de Ciencia y Tecnología Nuclear), J L Beard, J Beard (0000-0001-9089-6266), Hugues Vergnes (0000-0002-3511-5436, Instituto Boliviano de Ciencia y Tecnología Nuclear)
Year1979
Volume6
Issue6
Pages585-592
Publication date1979-01-01
Open AccessYes
TypeARTICLE
VenueAnnals of Human Biology (JOURNAL)
Journal identifiersISSN: 0301-4460 • E-ISSN: 1464-5033
PublisherInforma (PUBLISHER • GB)
DOI10.1080/03014467900003951
PMID583558
OpenAlexW2105900089
LanguageEN
Citations received5
References cited9

The stress of chronic hypobaric hypoxia present at high altitudes induces a series of adaptive changes in the intermediate metabolism in erythrocytes of high-altitude natives. Aymaras of the high Andean Plateau are shown to have within erythrocytes: (a) increased activity of NADH2 (GAPDH) generating stages, (b) decreased activity of NADH2 (LDH) consuming steps, (c) significantly increased methaemoglobin content, and (d) a large increase in the level of reduced glutathione. These alterations occur also in persons of the same ethnic group residing at low altitude. There is, however, only a moderate elevation of classic haematological parameters (erythrocyte count, haemoglobin and haematocrit) in highland natives. The functional implications of these metabolite changes are discussed with respect to regulation of erythrocyte metabolism

Altitude (triangle · Biology · Effects of high altitude on humans · Enzyme · Glutathione · Hemoglobin · Hypoxia (environmental · Metabolism · Methemoglobin · Oxygen · Chemistry · Erythrocyte Function and Pathophysiology · Heme Oxygenase-1 and Carbon Monoxide · High Altitude and Hypoxia · Medicine · Biochemistry · Internal Medicine · Physiology

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