HLA antigens in four Pacific populations with non-insulin-dependent diabetes mellitus

Bibliographic Data

ID13922397
AuthorsS W Serjeantson (Australian National University, corresponding author), D P Ryan (Caulfield Hospital), Paul Zimmet (0000-0003-0627-0776, Australian Red Cross Lifeblood), Richard Taylor (0000-0002-2625-088X), Rebecca Cross (0000-0003-3582-5996, Institut Pasteur de Nouvelle Calédonie), M Charpin (Australian National University), G Le Gonidec (Caulfield Hospital)
Year1982
Volume9
Issue1
Pages69-84
Publication date1982-01-01
Open AccessYes
TypeARTICLE
VenueAnnals of Human Biology (JOURNAL)
Journal identifiersISSN: 0301-4460 • E-ISSN: 1464-5033
PublisherInforma (PUBLISHER • GB)
DOI10.1080/03014468200005501
PMID7039491
OpenAlexW2150851343
LanguageEN
Citations received3
References cited28

HLA antigen distributions in persons with normal and abnormal glucose tolerance were compared in four Pacific populations. The populations included Melanesians from the Fijian Islands, Loyalty Islands and mainland New Caledonia and Polynesians from the Wallis Islands. HLA-DR results are provided for the first time for Pacific groups. In Polynesians, HLA-B22 was increased in frequency in patients with non-insulin-dependent diabetes mellitus and also in persons with impaired glucose tolerance. However, the association was not statistically significant when corrected for the number of antigens tested. A similar increase in HLA-B22, although not significant, was seen in each of the three Melanesian populations with abnormal glucose tolerance. No other consistent increase in any HLA antigen occurred in persons with abnormal plasma glucose concentrations

Antigen · Biology · Diabetes mellitus · Environmental health · Human leukocyte antigen · Mainland · Polynesians · Population · Atherosclerosis and Cardiovascular Diseases · Demography · Diabetes and associated disorders · Medicine · T-cell and B-cell Immunology · Ecology · Endocrinology · Immunology · Internal Medicine

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