Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14
Bibliographic Data
| ID | 14729647 |
|---|---|
| Authors | Peikun He (Southern Medical University), Hao Wang (0000-0003-3392-1562, Southern Medical University), Saibo Cheng (Southern Medical University), Fang Hu (0000-0002-3725-2936, Southern Medical University), Lifang Zhang (0000-0003-3177-6621, Southern Medical University), Weicong Chen (0000-0003-2751-897X, Southern Medical University), Yuling Xu (0000-0002-0684-3186, Fujian Medical University), Yaxin Zhang (0000-0003-4290-7076, Southern Medical University), Yuyan Gu (Southern Medical University), Zhaoyong Li (0000-0002-1502-4027, Southern Medical University), Yao Jin (0000-0001-9518-7063, Southern Medical University), Xiaoyu Liu (0000-0002-3485-0885, Southern Medical University Shenzhen Hospital, corresponding author), Yuhua Jia (0000-0001-6508-4418, Southern Medical University, corresponding author) |
| Year | 2023 |
| Volume | 314 |
| Pages | 116532 |
| Publication date | 2023-10-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2023.116532 |
| PMID | 37149071 |
| OpenAlex | W4368341071 |
| Language | EN |
| Citations received | 3 |
| References cited | 43 |
In summary, our findings suggest that geniposide protects ApoE -/- mice against WD-induced atherosclerosis by inducing M2 polarization of plaque macrophages via enhanced expression of CXCL14 in PVAT. These data provide novel insights into PVAT paracrine function in atherosclerosis and reaffirm geniposide as a therapeutic drug candidate for atherosclerosis treatment
Adipocyte · Adipose tissue · Chemokine · CXCL14 · In vitro · Inflammation · Macrophage · Macrophage polarization · Paracrine signalling · Receptor · Atherosclerosis and Cardiovascular Diseases · Cardiovascular Disease and Adiposity · Chemistry · Inflammasome and immune disorders · Medicine · Biochemistry · Cancer Research · Endocrinology · Internal Medicine · Pharmacology
| Unique citing works | 3 |
|---|---|
| Citations per year | 3 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 3 |