Dingxin recipe III ameliorates endothelial cell senescence in atherosclerosis by activating the Foxo3a/Pink1/Parkin axis

Bibliographic Data

ID14734973
AuthorsXiaoyu Liu (0000-0002-3485-0885, Shenzhen Sixth People's Hospital), Yao Jin (0000-0001-9518-7063, TCM-Intigrated Cancer Center of Southern Medical University), Jin Yao (0000-0003-2467-4635, TCM-Intigrated Cancer Center of Southern Medical University), Zhaoyong Li (0000-0002-1502-4027, TCM-Intigrated Cancer Center of Southern Medical University), Huashan Zhao, Hua-Shan Zhao (TCM-Intigrated Cancer Center of Southern Medical University), Xinghong Zhou (0000-0002-8066-1188, Dongguan University of Technology), Yanxin Zhu (0000-0002-6581-7367), Yi Zhu (0000-0001-6760-996X, TCM-Intigrated Cancer Center of Southern Medical University), Yuyan Gu (TCM-Intigrated Cancer Center of Southern Medical University), Lifang Zhang (0000-0003-3177-6621, TCM-Intigrated Cancer Center of Southern Medical University), Yaxin Zhang (0000-0003-4290-7076, TCM-Intigrated Cancer Center of Southern Medical University), Peikun He (University of Hong Kong - Shenzhen Hospital), Saibo Cheng (TCM-Intigrated Cancer Center of Southern Medical University), Yuling Xu (0000-0002-0684-3186, Fujian Medical University), Yuhua Jia (0000-0001-6508-4418, Southern Medical University Shenzhen Hospital)
Year2026
Volume354
Pages120525
Publication date2026-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120525
PMID40907726
OpenAlexW4413914021
LanguageEN
References cited37

Our findings for the first time demonstrated that DXRIII effectively alleviates endothelial senescence and HFD-induced AS, possibly by activating FOXO3a and subsequently enhancing PINK1/Parkin-mediated mitophagy

Disease · Parkin · PINK1 · Senescence · Adipokines, Inflammation, and Metabolic Diseases · Atherosclerosis and Cardiovascular Diseases · FOXO transcription factor regulation · Genetics, Aging, and Longevity in Model Organisms · Internal Medicine · Medicine · Pharmacology · Telomeres, Telomerase, and Senescence

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