Novel mechanisms of Anshen Dingzhi prescription against PTSD

Inhibiting DCC to modulate synaptic function and inflammatory responses

Bibliographic Data

ID14736873
AuthorsJiamin Hu (0000-0002-4105-342X, Anhui University of Traditional Chinese Medicine), Haipeng Li (0000-0001-7747-0180, Anhui University of Traditional Chinese Medicine), Xuncui Wang (Anhui University of Traditional Chinese Medicine), Hongliang Cheng (0009-0004-9994-7823, Anhui Medical University, corresponding author), Guoqi Zhu (0000-0001-7432-6079, Anhui University of Traditional Chinese Medicine, corresponding author), Shaojie Yang (0000-0001-5948-639X, Anhui Medical University, corresponding author)
Year2024
Volume333
Pages118425
Publication date2024-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118425
PMID38848974
OpenAlexW4399353543
LanguageEN
Citations received1
References cited47

Our data indicate that DCC is a key target for the regulation of synaptic function and inflammatory response in the onset of PTSD, and ADP likely reduces DCC to prevent PTSD via modulating downstream Rac1-PAK1 pathway. This study provides a novel mechanism for the onset of PTSD and warrants the clinical application of ADP

Antibody · Biology · Cancer · Colorectal cancer · Deleted in Colorectal Cancer · Hippocampal formation · Hippocampus · Immunofluorescence · Kinase · PAK1 · RAC1 · Signal transduction · Western blot · Cancer, Stress, Anesthesia, and Immune Response · Medicine · Neurogenesis and neuroplasticity mechanisms · Neuroinflammation and Neurodegeneration Mechanisms · Biochemistry · Cell Biology · Immunology · Internal Medicine · Pharmacology

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