Tribulus terrestris L. extract ameliorates atherosclerosis by inhibition of vascular smooth muscle cell proliferation in ApoE−/− mice and A7r5 cells via suppression of Akt/MEK/ERK signaling

Bibliographic Data

ID14737978
AuthorsJing Zhang (0000-0002-6431-9286, Shanghai University of Traditional Chinese Medicine), Wai-Rong Zhao (Shanghai University of Traditional Chinese Medicine), Wen-Ting Shi, Wenting Shi (0000-0002-3720-2189, Longhua Hospital Shanghai University of Traditional Chinese Medicine), Jun-Jie Tan (0000-0002-7505-0171, Shanghai Institute of Materia Medica), Kai-Yu Zhang (0000-0002-9346-6963, Shanghai University of Traditional Chinese Medicine), Jingyi Tang (0000-0002-8754-5809, Shanghai University of Traditional Chinese Medicine), Jing-Yi Tang, Xin-Lin Chen, Xinlin Chen (0000-0002-2650-8051, Shanghai University of Traditional Chinese Medicine, corresponding author), Zhong-Yan Zhou (0000-0002-2449-1380, Longhua Hospital Shanghai University of Traditional Chinese Medicine, corresponding author)
Year2022
Volume297
Pages115547
Publication date2022-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2022.115547
PMID35870688
OpenAlexW4286252853
LanguageEN
Citations received2
References cited60

FSEE presents potent anti- AS and VSMC proliferation activities and the underlying mechanism is likely to the suppression of Akt/MEK/ERK signaling. The active components of FSEE are JL-6 and its potential active pharmaceutical ingredients Tigo and Heco. So, FSEE and its active compounds may be potential therapeutic drug candidates for AS

Biology · Cell growth · MAPK/ERK pathway · Protein kinase B · Signal transduction · Smooth muscle · Vascular smooth muscle · Atherosclerosis and Cardiovascular Diseases · Medicine · Phytochemical Studies and Bioactivities · Phytochemistry and Bioactive Compounds · Biochemistry · Cancer Research · Cell Biology · Endocrinology · Pharmacology

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