Evaluation of alkylresorcinols in adipose tissue biopsies as a long-term biomarker of whole-grain wheat and rye intake in free-living Swedish men and women
Bibliographic Data
| ID | 15094359 |
|---|---|
| Authors | Huaxing Wu (0000-0002-8083-0797, Swedish University of Agricultural Sciences, corresponding author), Nor Adila Mhd Omar (0000-0003-1663-2689, Karolinska Institutet), Niclas Håkansson (0000-0001-7673-5554, Karolinska Institutet), Alicja Wolk (0000-0001-7387-6845, Uppsala University), Karl Michaëlsson (0000-0003-2815-1217, Uppsala University), Rikard Landberg (0000-0002-6399-7608, Karolinska Institutet) |
| Year | 2018 |
| Volume | 21 |
| Issue | 10 |
| Pages | 1933-1942 |
| Publication date | 2018-07-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980018000484 |
| PMID | 29547368 |
| OpenAlex | W2792588928 |
| Language | EN |
| References cited | 51 |
Objective Wheat and rye, the most consumed whole grains (WG) in the Nordic countries, contain alkylresorcinols (AR) in their bran. AR concentrations in human adipose tissue might reflect long-term WG rye and wheat intake. We aimed to evaluate AR concentrations in adipose tissue biopsies as a long-term biomarker of WG wheat and rye intake in free-living Swedish men and women. Design Cross-sectional study. AR concentrations in adipose tissue biopsies were analysed and compared with long-term WG intake assessed by three FFQ (repeated over a period of 14 years in men, 17 years in women) and with plasma AR concentrations. Setting The Cohort of Swedish Men between 1997 and 2010 and the Swedish Mammography Cohort between 1987 and 2003, Sweden. Subjects Men ( n 149) and women ( n 109). Results Long-term WG rye intake estimated with repeated FFQ correlated ( r =0·31–0·41, P r =0·17–0·33, P r =0·49–0·81, P Conclusions AR in adipose tissue reflected long-term WG rye but not WG wheat intake, probably due to poor precision in estimating WG wheat intake by FFQ. AR in adipose tissue appears promising as a biomarker of long-term WG rye intake but should be adjusted for sex
Adipose tissue · Animal science · Biology · Biomarker · Cohort · Chemistry · Folate and B Vitamins Research · Food composition and properties · Medicine · Nutritional Studies and Diet · Biochemistry · Endocrinology · Internal Medicine
| Highly cited | No |
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