Plasma alkylresorcinols, biomarkers of whole-grain intake, are not associated with progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
Bibliographic Data
| ID | 15095224 |
|---|---|
| Authors | Nicola M McKeown (0000-0002-1437-7533, Jean Mayer Human Nutrition Research Center on Aging, corresponding author), Adela Hruby (0000-0002-6549-4625, Harvard University), Rikard Landberg (0000-0002-6399-7608, Swedish University of Agricultural Sciences), David M Herrington (0000-0002-7670-6400, Atrium Health Wake Forest Baptist), Alice H Lichtenstein (0000-0002-1053-9478, Tufts University) |
| Year | 2016 |
| Volume | 19 |
| Issue | 2 |
| Pages | 326-331 |
| Publication date | 2016-02-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980015001123 |
| PMID | 25903091 |
| OpenAlex | W2275176211 |
| Language | EN |
| Citations received | 1 |
| References cited | 39 |
Objective The objective of the present study was to examine the relationship between plasma alkyresorcinol (AR) concentrations, which are biomarkers of whole-grain intake, and atherosclerotic progression over 3 years in postmenopausal women with coronary artery disease. Design Plasma AR concentrations were measured by a validated GC–MS method in fasting plasma samples. Atherosclerosis progression was assessed using change in mean minimal coronary artery diameter (MCAD) and percentage diameter stenosis (%ST), based on mean proximal vessel diameter across up to ten coronary segments. Dietary intake was estimated using a 126-item interviewer-administered FFQ. Setting A prospective study of postmenopausal women participating in the Estrogen Replacement and Atherosclerosis trial. Subjects For the analysis of plasma AR concentrations and atherosclerotic progression, plasma samples and follow-up data on angiography were available for 182 women. Results Mean whole-grain intake was 9·6 ( se 0·6) servings per week. After multivariate adjustment, no significant associations were observed between plasma AR concentrations and change in mean MCAD or progression of %ST. Plasma AR concentrations were significantly correlated with dietary whole grains ( r =0·35, P r =0·33, P r =0·15, P =0·05), total fibre ( r =0·22, P =0·003) and legume fibre ( r =0·15, P =0·04), but not refined grains, fruit fibre or vegetable fibre. Conclusions Plasma AR concentrations were not significantly associated with coronary artery progression over a 3-year period in postmenopausal women with coronary artery disease. A moderate association was observed between plasma AR concentrations and dietary whole grains and cereal fibre, suggesting it may be a useful biomarker in observational studies
Artery · Cardiology · Coronary artery disease · Coronary atherosclerosis · Prospective cohort study · Bariatric Surgery and Outcomes · Food composition and properties · Medicine · Nutritional Studies and Diet · Endocrinology · Internal Medicine
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| Citations per year | 0.13 |
|---|---|
| Citation span | 2018 - 2018 (1) |
| Highly cited | No |