Magnesium intake, insulin resistance and markers of endothelial function among women
Bibliographic Data
| ID | 15094392 |
|---|---|
| Authors | Narges Ghorbani Bavani (Isfahan University of Medical Sciences), Parvane Saneei (0000-0002-4605-7833, Isfahan University of Medical Sciences), Ammar Hassanzadeh Keshteli (0000-0001-7375-6210, University of Alberta), Ahmadreza Yazdannik (0000-0002-3026-3958, Iranshahr University), Ebrahim Falahi (0000-0001-9615-1089, Lorestan University of Medical Sciences), Omid Sadeghi (0000-0002-1029-1652, Tehran University of Medical Sciences), Ahmad Esmaillzadeh (0000-0002-8735-6047, Isfahan University of Medical Sciences, corresponding author) |
| Year | 2021 |
| Volume | 24 |
| Issue | 17 |
| Pages | 5777-5785 |
| Publication date | 2021-12-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980021001063 |
| PMID | 33719988 |
| OpenAlex | W3137514138 |
| Language | EN |
| References cited | 41 |
Objective: We investigated the association of dietary Mg intake with insulin resistance and markers of endothelial function among Iranian women. Design: A cross-sectional study. Setting: Usual dietary intakes were assessed using a validated FFQ. Dietary Mg intake was calculated by summing up the amount of Mg in all foods. A fasting blood sample was taken to measure serum concentrations of glycemic indices (fasting plasma glucose and insulin) and endothelial function markers (E-selectin, soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1). Insulin resistance and sensitivity were estimated using the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), Homeostasis Model Assessment β-cell function (HOMA-β) and quantitative insulin sensitivity check index (QUICKI). Participants: Iranian female nurses ( n 345) selected by a multistage cluster random sampling method. Results: The Mg intake across energy-adjusted quartiles was 205 ( se 7), 221·4 ( se 8), 254·3 ( se 7) and 355·2 ( se 9) mg/d, respectively. After adjustments for potential confounders, QUICKI level was significantly different across quartiles of Mg intake (Q 1 : 0·34 ( se 0·02), Q 2 : 0·36 ( se 0·01), Q 3 : 0·40 ( se 0·01), and Q 4 : 0·39 ( se 0·02), P = 0·02); however, this association disappeared after considering markers of endothelial function, indicating that this relation might be mediated through endothelial dysfunction. After controlling for all potential confounders, Mg intake was inversely, but not significantly, associated with serum concentrations of sICAM (Q 1 : 239 ( se 17), Q 2 : 214 ( se 12), Q 3 : 196 ( se 12), and Q 4 : 195 ( se 17), P = 0·29). There was no other significant association between dietary Mg intake and other indicators of glucose homoeostasis or endothelial markers. Conclusions: Higher dietary Mg intake was associated with better insulin sensitivity in Iranian females. This linkage was mediated through reduced endothelial dysfunction
Function (biology · Insulin · Insulin resistance · Insulin sensitivity · Linkage (software · Magnesium · Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
| Citation velocity | historical |
|---|---|
| Highly cited | No |