A high consumption of tomato and lycopene is associated with a lower risk of cancer mortality
Results from a multi-ethnic cohort
Bibliographic Data
| ID | 15096022 |
|---|---|
| Authors | Mohsen Mazidi (0000-0003-3059-229X, Chalmers University of Technology, corresponding author), Gordon A Ferns (0000-0002-0957-8349, Brighton and Sussex Medical School), Maciej Banach (0000-0001-6690-6874, Polish Mother’s Memorial Hospital Research Institute) |
| Year | 2020 |
| Volume | 23 |
| Issue | 9 |
| Pages | 1569-1575 |
| Publication date | 2020-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980019003227 |
| PMID | 32102720 |
| OpenAlex | W3008599846 |
| Language | EN |
| References cited | 45 |
Objective: We investigated the association between the consumption of tomato and lycopene and cancer mortality among US adults. Design: Prospective. Setting: The National Health and Nutrition Examination Survey (1999–2010). Participants: Participants with estimated dietary data on tomato and lycopene consumption were included. Outcome data up until 31 December 2011 were also ascertained. Cox proportional hazard regression models were used to relate baseline tomato and lycopene consumption with cancer mortality. We conducted a competing-risk survival analysis to account for deaths from other causes. Results: Adjusted Cox models showed that tomato and lycopene intake were inversely related (hazard ratio (95 % CI)) to cancer mortality: 0·86 (0·81, 0·92) and 0·79 (0·74, 0·82), respectively. In the adjusted competing-risk models, the sub-hazard ratios (95 % CI) were 0·89 (0·83, 0·94) and 0·82 (0·78, 0·86) for cancer mortality for tomato and lycopene intake, respectively. No significant interaction was found for the association between tomato and lycopene consumption and cancer mortality while comparing older (aged >50 years) v . younger adults ( P interaction > 0·173 for all) and obese v . non-obese ( P interaction > 0·352 for all). Conclusions: Our results demonstrate the potential beneficial effects of a high dietary intake of tomato and lycopene on cancer death. Further prospective studies are needed to explore the association
Biology · Cancer · Carotenoid · Cohort study · Confidence interval · Environmental health · Hazard ratio · Lower risk · Lycopene · Proportional hazards model · Prospective cohort study · Antioxidant Activity and Oxidative Stress · Cancer, Lipids, and Metabolism · Demography · Medicine · Nutritional Studies and Diet · Food Science · Internal Medicine
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| Citation velocity | historical |
|---|---|
| Highly cited | No |