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Crack-cocaine use practices, harms and respiratory problems

An analysis of gender differences using data from a cross-sectional survey in England

Bibliographic Data

ID15375543
AuthorsVivian D Hope (Liverpool John Moores University, corresponding author), Caitlynne McGaff (Royal Society of Tropical Medicine and Hygiene), Casey Sharpe (0000-0002-0560-7341, Royal Society of Tropical Medicine and Hygiene), Sachinkumar Rathod (0000-0001-8783-7724, Royal Society of Tropical Medicine and Hygiene), Sujit D Rathod (Royal Society of Tropical Medicine and Hygiene), Lucy Platt (0000-0002-0943-0045, Royal Society of Tropical Medicine and Hygiene), Jenny Scott (0000-0002-4920-0914, University of Bristol), SIPP Project Team, Joanna Busza (0000-0001-6334-0318), Stuart Sweeney (0000-0003-4233-9080), Sedona Sweeney, Lorna Guinne (0000-0002-1013-4200), Lorna Guinness, Cedomir Vuckovic, Ian Yoon, Alexandre Piot (0000-0002-4019-5127), Andrew Preston (0000-0003-3381-4839), Niamh Eastwood, Louise Wilkins, Shoba Ram, Carol Lord (0000-0002-2085-5378), Catherine Lord (0000-0001-5633-1253), Philippe Bonnet (0000-0002-0234-5374), Peter Furlong, Magdalena Harris (0000-0001-8718-8226, Royal Society of Tropical Medicine and Hygiene)
Year2026
Volume26
Issue1
Publication date2026-04-02
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueBMC Public Health (JOURNAL)
Journal identifiersISSN: 1471-2458 • E-ISSN: 1471-2458
PublisherBioMed Central (PUBLISHER • GB)
DOI10.1186/s12889-026-27073-1
PMID41923056
OpenAlexW7147110391
LanguageEN
References cited53

The use of stimulants, such as crack-cocaine, is a global public health concern. Crack-cocaine use is increasing in the UK, but available data is focused on those who inject or also use opioids. To address this gap, characteristics of people using crack-cocaine in England, including respiratory problems among those who smoke, and variation in these by gender are described. Adults self-reporting crack-cocaine use in the past 28 days, recruited by specialist services and peer networks in six sites during 2023, completed a self-report survey about demographic characteristics, drug use, crack use practices, health problems and service use. Bivariable analyses and logistic regression were used to explore gender-related differences in crack-cocaine use and crack-related respiratory problems. The participants’ (n = 731) median age was 42 years and 71% were men. Overall, 54% were stably housed, 71% had ever been imprisoned and 28% reported emergency department attendance in past 6 months. In the past 28 days, 99% had smoked crack-cocaine (44% shared pipes), with 30% injecting crack. Poly-sedative use was common including heroin (78%), pregabalin/gabapentin (41%), and benzodiazepines (28%), with 62% receiving opioid substitution therapy. Use of drugs normally smoked was common (90% tobacco, 62% cannabis and 25% spice). Women reported less polydrug use but more often vaped nicotine. Crack-related respiratory symptoms among those smoking crack were reported by 67% of women and 58% of men. In both men and women these symptoms were associated with increasing time since first crack-cocaine use and pregabalin/gabapentin use. In men they were also associated with food insecurity; smoking tobacco; temporary employment; and use in abandoned buildings or at friend’s place; reduced odds were associated with current heroin use and using with a close friend. Among women, having a respiratory symptom was also associated with sharing pipes. Respiratory health problems are common among those smoking crack-cocaine, particularly among women. In combination with high poly-sedative use, this poses a mortality risk from respiratory depression. UK service provision is focused on prevention of opiate and injection-related risks. Services for people who use crack-cocaine and low-threshold respiratory care pathways require prioritisation to reduce avoidable morbidity and mortality

Attendance · Biostatistics · Cannabis · Heroin · Logistic regression · Marital status · Public health · Forensic Toxicology and Drug Analysis · HIV, Drug Use, Sexual Risk · Substance Abuse Treatment and Outcomes · Epidemiology

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