The Associations between the Duration of Folic Acid Supplementation, Gestational Diabetes Mellitus, and Adverse Birth Outcomes based on a Birth Cohort
Bibliographic Data
| ID | 15469593 |
|---|---|
| Authors | Gang Cheng (0000-0002-1760-9539, Central South University), Tingting Sha (0000-0002-8559-2150, Central South University), Xiao Gao (0000-0003-4042-8362, Central South University), Qiong He (0000-0002-4753-4830, Central South University), Xialing Wu (0000-0003-0639-9860, Central South University), Qianling Tian (0000-0003-3104-2695, Central South University), Fan Yang (0000-0003-2978-7102, Central South University), Cai Tang (Central South University), Xihong Wu (0009-0004-5236-7469, Central South University), Qunhui Xie (Central South University), Yan Yan (0000-0001-5357-0187, Central South University, corresponding author) |
| Year | 2019 |
| Volume | 16 |
| Issue | 22 |
| Pages | 4511-4511 |
| Publication date | 2019-11-15 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | International Journal of Environmental Research and Public Health (JOURNAL) |
| Journal identifiers | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph16224511 |
| PMID | 31731641 |
| OpenAlex | W2983981417 |
| Language | EN |
| References cited | 43 |
This study aimed to examine the associations between the duration of folic acid (FA) supplementation, gestational diabetes mellitus (GDM), and adverse birth outcomes. A total of 950 mother-offspring pairs participated in the cohort study during 2015 in Changsha, China. The data were collected through home visits and perfected by maternal and child healthcare handbooks. Generalized linear models and stratified analyses were used for statistical analyses. The incidence of GDM in our cohort was 10.2%. FA supplementation for ≥3 months before pregnancy was associated with an increased risk of GDM (adjusted relative risk (aRR): 1.72; 95% CI: 1.17-2.53) and decreased risk of small-for-gestational-age (SGA) birth (aRR: 0.40; 95% CI: 0.18-0.88). In the group of FA supplementation for ≥3 months during pregnancy, GDM was associated with an increased risk of cesarean delivery (aRR: 1.36; 95% CI: 1.06-1.75) and macrosomia (aRR: 2.11; 95% CI: 1.06, 4.20), but the aRRs were lower than the RR MH 1.53 (95% CI: 1.01-2.34) and 2.43 (95% CI: 1.27-4.66). Our study suggested that the longer duration of FA supplementation before pregnancy might increase the risk of GDM, but decrease the risk of SGA birth. Longer duration of FA supplementation during pregnancy had beneficial effects on birth outcomes in women with GDM. Further studies should consider a larger sample size to confirm these findings
Adverse effect · Biology · Cohort · Cohort study · Diabetes mellitus · folic acid · Folic acid supplementation · Gestation · Gestational diabetes · Obstetrics · Pregnancy · Folate and B Vitamins Research · Gestational Diabetes Research and Management · Medicine · Pregnancy and preeclampsia studies · Endocrinology · Internal Medicine · Pediatrics
| Citation velocity | historical |
|---|---|
| Highly cited | No |