Implications of Combined Exposure to Household Air Pollution and HIV on Neurocognition in Children
Dados Bibliográficos
| ID | 15469852 |
|---|---|
| Autores | Megan Suter (0000-0001-8494-3548, University of Washington), Catherine J Karr (0000-0002-4683-2270, University of Washington), Grace John‐Stewart (0000-0002-4301-1573, University of Washington), Laurén Gómez (0000-0003-2731-0781, University of Washington), Hellen Moraa (0000-0001-8862-3058, University of Nairobi), Duke Nyatika (University of Nairobi), Dalton Wamalwa (0000-0002-5510-462X, University of Nairobi), Michael Paulsen (0000-0002-8229-6567, University of Washington), Christopher D Simpson (0000-0001-7122-371X, University of Washington), Niloufar Ghodsian (University of Washington), Michael J Boivin (0000-0002-0097-1777, Michigan State University), Paul Bangirana (0000-0002-7136-0594, Makerere University), Sarah Benki‐Nugent (0000-0002-3034-8257, University of Washington, autor correspondente) |
| Ano | 2018 |
| Volume | 15 |
| Fascículo | 1 |
| Páginas | 163-163 |
| Data de publicação | 2018-01-20 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | International Journal of Environmental Research and Public Health (JOURNAL) |
| Identificadores do periódico | ISSN: 1661-7827 • E-ISSN: 1660-4601 |
| Editora | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/ijerph15010163 |
| PMID | 29361707 |
| OpenAlex | W2791894185 |
| Idioma | EN |
| Citações recebidas | 1 |
| Referências citadas | 5 |
Air pollution exposure and HIV infection can each cause neurocognitive insult in children. The purpose of this study was to test whether children with combined high air pollution exposure and perinatal HIV infection have even greater risk of neurocognitive impairment. This was a cross-sectional study of HIV-uninfected unexposed (HUU) and HIV-infected children and their caregivers in Nairobi, Kenya. We used a detailed neuropsychological battery to evaluate neurocognitive functioning in several domains. We measured caregiver 24-h personal CO exposure as a proxy for child CO exposure and child urinary 1-hydroxypyrene (1-OHP), a biomarker for exposure to polycyclic aromatic hydrocarbons (PAHs). Median 24-h caregiver CO exposure was 6.1 and 3.7 ppm for 45 HIV-infected (mean age 6.6 years) and 49 HUU (mean age 6.7 years), respectively; 48.5% of HIV-infected and 38.6% of HUU had caregiver 24-h CO levels exceeding the WHO recommended level. Median 1-OHP exposure was 0.6 and 0.7 μmol/mol creatinine among HIV-infected and HUU children, respectively. HIV-infected children with high urinary 1-OHP (exceeding 0.68 μmol/mol creatinine) had significantly lower global cognition ( p = 0.04), delayed memory ( p = 0.01), and attention scores ( p = 0.003). Among HUU children, urinary 1-OHP and caregiver 24-h caregiver CO were not significantly associated with neurocognitive function. Our findings suggest that combined chronic exposure to air pollutants and perinatal HIV infection may be associated with poorer neurocognitive outcomes. High prevalence of air pollution exposure highlights the need to reduce these exposures
Cognition · Environmental health · Human immunodeficiency virus (HIV · Neurocognitive · Psychiatry · Urinary system · Air Quality and Health Impacts · Energy and Environment Impacts · Health, Environment, Cognitive Aging · Medicine · Immunology · Internal Medicine · Pediatrics · Physiology
| Obras citantes distintas | 1 |
|---|---|
| Citações por ano | 0,17 |
| Intervalo de citações | 2020 - 2020 (1) |
| Velocidade de citação | historical |
| Altamente citado | Não |
| Tipos de citação | Neutras: 1 |