Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure

Bibliographic Data

ID15480264
AuthorsJuneyoung Lee (0000-0001-8073-9304, Ewha Womans University), Dirga Kumar Lamichhane (0000-0002-9263-3707, Inha University), Myeongjee Lee (0000-0003-2368-5180, Ewha Womans University), Shinhee Ye (0000-0003-4238-130X, Ewha Womans University), Jung-Hyun Kwon (Korea University), Myung‐Sook Park (0000-0002-7629-3511), Hwan‐Cheol Kim (0000-0002-3635-1297, Inha University), Jong‐Han Leem (0000-0003-3292-6492, Inha University), Yun‐Chul Hong (0000-0001-9010-7271, Seoul National University), Yangho Kim (0000-0002-6462-0829, University of Ulsan), Mina Ha (0000-0003-1011-9446, Dankook University), Eun‐Hee Ha (0000-0002-4224-3858, Ewha Womans University, corresponding author)
Year2018
Volume15
Issue1
Pages102-102
Publication date2018-01-09
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueInternational Journal of Environmental Research and Public Health (JOURNAL)
Journal identifiersISSN: 1661-7827 • E-ISSN: 1660-4601
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph15010102
PMID29315266
OpenAlexW2783151243
LanguageEN
Citations received5
References cited7

Few birth cohort studies have examined the role of traffic-related air pollution (TRAP) in the development of infantile atopic dermatitis (AD), but none have investigated the role of preventive factors such as green spaces. The aim of this study was to investigate whether exposure to nitrogen dioxide (NO2) and particulate matter with an aerodynamic diameter of 10 ) during pregnancy is associated with increased risk of development of AD in 6-month-old children and also to examine how this association changes with residential green space. This study used prospective data from 659 participants of the Mothers and Children's Environmental Health study. Subjects were geocoded to their residential addresses and matched with air pollution data modeled using land-use regression. Information on infantile AD was obtained by using a questionnaire administered to the parents or guardians of the children. The association between infantile AD and exposure to NO2 and PM 10 was determined using logistic regression models. We assessed the effects of residential green spaces using stratified analyses and by entering product terms into the logistic regression models. The risk of infantile AD significantly increased with an increase in air pollution exposure during the first trimester of pregnancy. The adjusted odds ratio (OR) and 95% confidence interval (CI) were 1.219 (1.023-1.452) per 10 μg/m3 increase in PM 10 and 1.353 (1.027-1.782) per 10 ppb increase in NO2. An increase in the green space within 200 m of residence was associated with a decreased risk of AD (OR = 0.996, 95% CI: 0.993-0.999). The stratified analysis of residential green space revealed stronger associations between infantile AD and PM 10 and NO2 exposure during the first trimester in the areas in the lower tertiles of green space. This study indicated that exposure to TRAP during the first trimester of pregnancy is associated with infantile AD. Less residential green space may intensify the association between TRAP exposure and infantile AD

Air pollution · Atopic dermatitis · Confidence interval · Environmental health · Logistic regression · Odds ratio · Pregnancy · Allergic Rhinitis and Sensitization · Demography · Dermatology and Skin Diseases · Medicine · Urban Green Space and Health · Immunology · Pediatrics

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