P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients
Bibliographic Data
| ID | 15517967 |
|---|---|
| Authors | Chen-Lan Shen (National Taiwan University), Tsu-Lung Chou (0000-0002-5039-7793, National Taiwan University), Tai-Li Chou, Wen‐Sung Lai (0000-0001-6918-5531, National Taiwan University), Wen-Sung Lai, Ming H Hsieh (0000-0002-3585-7843, National Taiwan University Hospital, corresponding author), Chen‐Chung Liu (0000-0002-9290-110X, National Taiwan University), Chen-Chung Liu, Chih‐Min Liu (0000-0001-7016-8990, National Taiwan University), Chih-Min Liu, Hai‐Gwo Hwu (0000-0002-2582-2807, National Taiwan University) |
| Year | 2020 |
| Volume | 11 |
| Pages | 868-868 |
| Publication date | 2020-08-27 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2020.00868 |
| PMID | 33192632 |
| OpenAlex | W3082494264 |
| Language | EN |
| Citations received | 5 |
| References cited | 89 |
Till date, this study has the largest sample size to analyze P50, N100, and P200 collectively by adopting the passive auditory paired-click paradigm without distractors. With covariates controlled for possible confounds, such as age, education, smoking amount and retained pairs, we found that schizophrenia patients had significant sensory gating deficits in P50-N100-P200. The schizophrenia patients had demonstrated a unique pattern of sensory gating deficits, including repetition suppression deficits in P50 and stimulus registration deficits in N100/200. These results suggest that sensory gating is a pervasive cognitive abnormality in schizophrenia patients that is not limited to the pre-attentive phase of information processing. Since P200 exhibited a large effect size and did not require additional time during recruitment, future studies of P50-N100-P200 collectively are highly recommended
Audiology · Cognition · Electroencephalography · Endophenotype · Event-related potential · Gating · N100 · P200 · Perception · Psychiatry · Schizophrenia (object-oriented programming · Sensory gating · Visual perception · Hearing Loss and Rehabilitation · Medicine · Neuroscience · Neuroscience and Music Perception · Psychology · Schizophrenia research and treatment
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| Citations per year | 1 |
|---|---|
| Citation span | 2021 - 2026 (6) |
| Highly cited | No |