The mesolimbic system and the loss of higher order network features in schizophrenia when learning without reward
Bibliographic Data
Our analytical goals were linked to a recent circuit-based integrative model which argued that synergy between learning and reward circuits is lost in schizophrenia. The model's notable prediction was that such a loss would be observed even when patients learned without reward. Our results provide substantial support for these predictions where we observed a loss of network features between the brain's sub-circuits for a) learning (including the hippocampus and prefrontal cortex) and b) reward processing (specifically constituents of the mesolimbic system that included the ventral tegmental area and the nucleus accumbens. Our findings motivate a renewed appraisal of the relationship between reward and cognition in schizophrenia and we discuss their relevance for putative behavioral interventions
Associative learning · Associative property · Cognition · Cognitive psychology · Cued speech · Schizophrenia (object-oriented programming · Task (project management · Functional Brain Connectivity Studies · Mental Health Research Topics · Neural dynamics and brain function · Neuroscience · Psychology
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