The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD
Bibliographic Data
| ID | 15524337 |
|---|---|
| Authors | Yifei Weng (0000-0003-3464-7067, Nanjing General Hospital of Nanjing Military Command), Rongfeng Qi (0000-0002-9981-9918, Nanjing University), Feng Chen (0000-0002-9129-7895, Haikou City People's Hospital), Jun Ke (0000-0002-7792-8566, Soochow University), Qiang Xu (0000-0001-7149-0359, Nanjing University), Yuan Zhong (0000-0001-6295-7711, Nanjing Medical University), Li‐Da Chen (0000-0001-9904-2195, Central South University), Jianjun Li (0000-0003-2872-9648, Haikou City People's Hospital), Zhiqiang Zhang (0000-0002-0083-7455, Nanjing University, corresponding author), Li Zhang (0000-0002-4441-5131, Central South University, corresponding author), Guang Ming Lu (0000-0003-4913-2314, Nanjing Medical University, corresponding author) |
| Year | 2018 |
| Volume | 9 |
| Pages | 218-218 |
| Publication date | 2018-05-25 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2018.00218 |
| PMID | 29887811 |
| OpenAlex | W2803086687 |
| Language | EN |
| References cited | 9 |
The abnormal brain activity is a pivotal condition for the occurrence of posttraumatic stress disorder. However, the dynamic time features of intrinsic brain activities still remain unclearly in PTSD patients. Our study aims to perform the resting-state lag analysis (RS-LA) method to explore potential propagated patterns of intrinsic brain activities in PTSD patients. We recruited 27 drug-naive patients with PTSD, 33 trauma-exposed controls (TEC), and 30 demographically matched healthy controls (HC) in the final data statistics. Both RS-LA and conventional voxel-wise functional connectivity strength (FCS) methods were employed on the same dataset. Then, Spearman correlation analysis was conducted on time latency values of those abnormal brain regions with the clinical assessments. Compared with HC group, the time latency patterns of PTSD patients significantly shifted toward later in posterior cingulate cortex/precuneus, middle prefrontal cortex, right angular, and left pre- and post-central cortex. The TEC group tended to have similar time latency in right angular. Additionally, significant time latency in right STG was found in PTSD group relative to TEC group. Spearman correlation analysis revealed that the time latency value of mPFC negatively correlated to the PTSD checklist-civilian version scores (PCL_C) in PTSD group ( r = -0.578, P < 0.05). Furthermore, group differences map of FCS exhibited parts of overlapping areas with that of RS-LA, however, less specificity in detecting PTSD patients. In conclusion, apparent alterations of time latency were observed in DMN and primary sensorimotor areas of PTSD patients. These findings provide us with new evidence to explain the neural pathophysiology contributing to PTSD
Anterior cingulate cortex · Audiology · Cognition · Correlation · Cortex (anatomy · Latency (audio · Posterior cingulate · Precuneus · Prefrontal cortex · TEC · Functional Brain Connectivity Studies · Health, Environment, Cognitive Aging · Medicine · Mental Health Research Topics · Neuroscience · Psychology · Internal Medicine
A Rating Instrument For Anxiety Disorders
Clinician-administered PTSD scale
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Psychometric properties of the PTSD checklist—civilian version
Dparsf
The epidemiology of traumatic event exposure worldwide
Functional connectivity in the resting brain
Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion
A default mode of brain function
| Citation velocity | historical |
|---|---|
| Highly cited | No |